269399-35-1

Upstream product

• 113019-11-7 2-(((4-methoxyphenyl)diphenylmethyl)amino)ethanol 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 261622-09-7 N-4-methoxytritylglycine methyl ester 

Downstream Products

• 651028-09-0 3,6,9,12-tetra-(2,4-dinitrobenzenesulfonyl)-3,6,9,12-tetraaza-1,14-bis((4-methoxytrityl)amino)tetradecane 

Relevant academic research and scientific papers

Epoxidation of peptidyl olefin isosteres. Stereochemical induction effect of chiral centers at four adjacent C(α) positions

Four tripeptidyl olefin isosteres were prepared, each of which contains a single chiral center derived from the bulky amino acid phenylalanine at positions corresponding to the P2-P'2 positions of a protease substrate. The effect of these chiral centers on the stereochemical outcome of mCPBA epoxidation of the olefin functionality was studied. A chiral center at P2 or P'2 position has no significant effect, and the P'1 position exerts a small stereoselectivity. A chiral center at the P1 position, on the other hand, has a profound chiral induction effect on the epoxidation reaction. (C) 2000 Elsevier Science Ltd.