269404-07-1

Basic information

• Product Name: 5,6,7,8-tetrahydro-5-(4-methylphenylsulfonyl)pyrido[3,2-b]azepin-9-one
• Synonyms: 5,6,7,8-tetrahydro-5-(4-methylphenylsulfonyl)pyrido[3,2-b]azepin-9-one
• CAS NO: 269404-07-1
• Molecular Weight: 316.381
• Mol File: 269404-07-1.mol

Chemical Properties

• CAS DataBase Reference: 5,6,7,8-tetrahydro-5-(4-methylphenylsulfonyl)pyrido[3,2-b]azepin-9-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6,7,8-tetrahydro-5-(4-methylphenylsulfonyl)pyrido[3,2-b]azepin-9-one(269404-07-1)
• EPA Substance Registry System: 5,6,7,8-tetrahydro-5-(4-methylphenylsulfonyl)pyrido[3,2-b]azepin-9-one(269404-07-1)

Safety Data

• Hazardous Substances Data: 269404-07-1(Hazardous Substances Data)

Upstream product

• 67203-48-9 6,7,8,9-tetrahydro-5H-pyrido[3,2-b]azepine 
• 269404-05-9 6,7,8,9-tetrahydro-9-hydroxy-5-(4-methylphenylsulfonyl)-5H-pyrido[3,2-b]azepine O-acetate 
• 269404-04-8 6,7,8,9-tetrahydro-5-(4-methylphenylsulfonyl)-5H-pyrido[3,2-b]azepine N-oxide 
• 269404-03-7 6,7,8,9-tetrahydro-5-(4-methylphenulsulfonyl)-5H-pyrido[3,2-b]azepine 
• 98-59-9 p-toluenesulfonyl chloride 
• 269404-06-0 6,7,8,9-tetrahydro-9-hydroxy5-(4-methylphenylsulfonyl)-5H-pyrido[3,2-b]azepine 

Downstream Products

• 269404-10-6 1,4,5,6-tetrahydro-6-(4-methylphenylsulfonyl)pyrazolo[3,4-d]pyrido[3,2-b]azepine 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS

The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Synthesis of 1,4,5,6-tetrahydropyrazolo[3,4-d]pyrido[3,2-b]azepine

The synthesis of 7,8-dihydro-5(6H)-quinolinone (3) from commercially available 3-amino-2-cyclohexen-1-one (1) and 3-(dimethylamino)acrolein (4) in 23% yield avoids the preparation of propynal (2). Conversion of 5-(4- methylphenylsulfonyl)-6,7,8,9-tetrahydro-5H-pyrido[3,2-b]azepine (12) to 6- (4-methylphenylsulfonyl)-1,4,5,6-tetrahydropyrazolo[3,4-d]pyrido[3,2- b]azepine (24) is described. Removal of the N-(4-methylphenylsulfonyl) group with 40% sulfuric acid in acetic acid gave the tricyclic azepine 26. Application of a similar series of reactions to 5-(4-nitrobenzoyl)-6,7,8,9- tetrahydro-5H-pyrido[3,2-b]azepine (13) afforded 6-(4-nitrobenzoyl)-1,4,5,6- tetrahydropyrazolo[3,4-d]pyrido[3,2-b]azepine (25).