269404-06-0

Basic information

• Product Name: 6,7,8,9-tetrahydro-9-hydroxy5-(4-methylphenylsulfonyl)-5H-pyrido[3,2-b]azepine
• Synonyms: 6,7,8,9-tetrahydro-9-hydroxy5-(4-methylphenylsulfonyl)-5H-pyrido[3,2-b]azepine
• CAS NO: 269404-06-0
• Molecular Weight: 318.397
• Mol File: 269404-06-0.mol

Chemical Properties

• CAS DataBase Reference: 6,7,8,9-tetrahydro-9-hydroxy5-(4-methylphenylsulfonyl)-5H-pyrido[3,2-b]azepine(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7,8,9-tetrahydro-9-hydroxy5-(4-methylphenylsulfonyl)-5H-pyrido[3,2-b]azepine(269404-06-0)
• EPA Substance Registry System: 6,7,8,9-tetrahydro-9-hydroxy5-(4-methylphenylsulfonyl)-5H-pyrido[3,2-b]azepine(269404-06-0)

Safety Data

• Hazardous Substances Data: 269404-06-0(Hazardous Substances Data)

Upstream product

• 67203-48-9 6,7,8,9-tetrahydro-5H-pyrido[3,2-b]azepine 
• 269404-04-8 6,7,8,9-tetrahydro-5-(4-methylphenylsulfonyl)-5H-pyrido[3,2-b]azepine N-oxide 
• 269404-03-7 6,7,8,9-tetrahydro-5-(4-methylphenulsulfonyl)-5H-pyrido[3,2-b]azepine 
• 98-59-9 p-toluenesulfonyl chloride 
• 269404-05-9 6,7,8,9-tetrahydro-9-hydroxy-5-(4-methylphenylsulfonyl)-5H-pyrido[3,2-b]azepine O-acetate 

Downstream Products

• 269404-10-6 1,4,5,6-tetrahydro-6-(4-methylphenylsulfonyl)pyrazolo[3,4-d]pyrido[3,2-b]azepine 
• 269404-07-1 5,6,7,8-tetrahydro-5-(4-methylphenylsulfonyl)pyrido[3,2-b]azepin-9-one 

Relevant articles and documents

Synthesis of 1,4,5,6-tetrahydropyrazolo[3,4-d]pyrido[3,2-b]azepine

The synthesis of 7,8-dihydro-5(6H)-quinolinone (3) from commercially available 3-amino-2-cyclohexen-1-one (1) and 3-(dimethylamino)acrolein (4) in 23% yield avoids the preparation of propynal (2). Conversion of 5-(4- methylphenylsulfonyl)-6,7,8,9-tetrahydro-5H-pyrido[3,2-b]azepine (12) to 6- (4-methylphenylsulfonyl)-1,4,5,6-tetrahydropyrazolo[3,4-d]pyrido[3,2- b]azepine (24) is described. Removal of the N-(4-methylphenylsulfonyl) group with 40% sulfuric acid in acetic acid gave the tricyclic azepine 26. Application of a similar series of reactions to 5-(4-nitrobenzoyl)-6,7,8,9- tetrahydro-5H-pyrido[3,2-b]azepine (13) afforded 6-(4-nitrobenzoyl)-1,4,5,6- tetrahydropyrazolo[3,4-d]pyrido[3,2-b]azepine (25).