269409-74-7Relevant academic research and scientific papers
SAR Exploration of Tight-Binding Inhibitors of Influenza Virus PA Endonuclease
Credille, Cy V.,Morrison, Christine N.,Stokes, Ryjul W.,Dick, Benjamin L.,Feng, Yifan,Sun, Jiaxing,Chen, Yao,Cohen, Seth M.
supporting information, p. 9438 - 9449 (2019/10/28)
Significant efforts have been reported on the development of influenza antivirals including inhibitors of the RNA-dependent RNA polymerase PA N-terminal (PAN) endonuclease. Based on recently identified, highly active metal-binding pharmacophore
Design, synthesis, and structure-activity relationships of aminopyridine N-oxides, a novel scaffold for the potent and selective inhibition of p38 mitogen activated protein kinase
Lumeras, Wenceslao,Caturla, Francisco,Vidal, Laura,Esteve, Cristina,Balagué, Cristina,Orellana, Adelina,Domínguez, María,Roca, Ramón,Huerta, Josep M.,Godessart, Núria,Vidal, Bernat
experimental part, p. 5531 - 5545 (2010/02/28)
A novel series of aminopyridine N-oxides were designed, synthesized, and tested for their ability to inhibit p38α MAP kinase. Some of these compounds showed a significant reduction in the LPS-induced TNFR production in human whole blood. Structure-activit
HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
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Page/Page column 145, (2008/12/05)
Provided herein are Heteroaryl Compounds having the following structure: (I) wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.
NOVEL COMPOUNDS
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Page/Page column 180-181, (2010/11/29)
Novel substituted 1,5,7-trisubstituted-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2-(1H)-one compounds and compositions, and their use in therapy as CSBP/RK/p38 kinase inhibitors.
NOVEL COMPOUNDS
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Page/Page column 200-201, (2008/06/13)
Novel substituted l,5,7-trisubstituted-354-dihydro-pyriinido[4,5-(flpyrimidin- 2-(2H)-one compounds and compositions, and their use in therapy as CSBP/RK/p38 kinase inhibitors.
