26952-91-0Relevant academic research and scientific papers
Zn(II)-Catalyzed One-Pot Synthesis of Coumarins from Ynamides and Salicylaldehydes
Yoo, Huen Ji,Youn, So Won
, p. 3422 - 3426 (2019/05/10)
A highly efficient and straightforward synthesis of diversely substituted coumarins from ynamides and salicylaldehydes in the presence of Zn(II) catalyst has been developed. The sulfonamide moiety of ynamides was successfully recycled in this process, serving as an effective traceless directing group for high regioselectivity in the bond-forming event. The advantages of this protocol are good functional group tolerance, broad substrate scope, simple and high-yielding reaction, recovery/reuse of the sulfonamides, low catalyst loading of inexpensive catalyst, and, by these merits, a more cost-effective and greener process.
Regioselective Chlorination and Suzuki–Miyaura Cross-Coupling of 4-Alkoxycoumarins, 4-Alkoxy-2-pyrones, and Related Heterocycles
Prendergast, Aisling M.,McGlacken, Gerard P.
, p. 4827 - 4835 (2017/09/07)
Chlorination of the coumarin framework was achieved by using trichloroisocyanuric acid, which has several advantages over N-chlorosuccinimide, particularly with respect to cost-effectiveness and toxicity. The Suzuki–Miyaura cross-coupling of the chlorinat
Pd/pivalic acid mediated direct arylation of 2-pyrones and related heterocycles
Pardo, Leticia M.,Prendergast, Aisling M.,Nolan, Marie-T.,Muimhneachin, Eoin,McGlacken, Gerard P.
, p. 3540 - 3550 (2015/06/08)
Abstract Direct arylation represents a favourable alternative to traditional cross-coupling reactions and has found widespread use with simple aryls and robust heterocycles. Herein a direct arylation protocol has been optimised and applied to more delicat
