26957-01-7Relevant academic research and scientific papers
Synthesis of 5-Substituted 1-Hydroxy-1,2,3-triazoles through Directed Lithiation of 1-(Benzyloxy)-1,2,3-triazole
Uhlmann, Peter,Felding, Jakob,Vedso, Per,Begtrup, Mikael
, p. 9177 - 9181 (2007/10/03)
1-(Benzyloxy)-1,2,3-triazole, prepared by selective benzylation of 1-hydroxy-1,2,3-triazole or by oxidative cyclization of 2-hydrazonoglyoxal O-benzyloxime, was metalated exclusively at the 5-position upon treatment with n-butyllithium. The anion formed reacted with a series of electrophiles. In this way carbon, halogen, sulfur, silicon, and tin substituants could be introduced at the 5-position. Subsequent removal of the benzyl group by palladium-catalyzed hydrogenolysis or by treatment with hydrochloric acid afforded the corresponding 5-substituted 1-hydroxy-1,2,3- triazoles.
3-Substituted 1,2,3-Triazole-1-Oxides. Preparation and Reactions
Begtup, Mikael,Jonsson, Gujion
, p. 724 - 735 (2007/10/02)
1-Substituted triazoles and m-chloroperbenzoic acid produce 3-substituted triazole-1-oxides, activated towards electrophiles, nucleophiles and deprotonation.Thus, the N-oxides are alkylated at the N-oxygen.They are chlorinated of brominated at C-5.Methoxi
