26958-67-8Relevant academic research and scientific papers
Ruthenium-catalyzed synthesis of 1,3,5-triazin-2(1: H)-ones and dihydro[1,3,5]triazino[1,2- a] benzimidazoles from alcohols and guanides
Zeng, Ming,Xie, Zhong Pao,Cui, Dong-Mei,Zhang, Chen
, p. 11905 - 11907 (2018)
An efficient ruthenium-catalyzed synthesis of tri-substituted 1,3,5-triazinones from alcohols and guanylureas under mild conditions has been developed. The scope of both the alcohols and guanylureas in the reaction is demonstrated. This ruthenium-catalyzed ring-forming process can be successfully extended to 2-guanidinobenzimidazoles to afford substituted dihydro[1,3,5]triazino[1,2-a]benzimidazoles.
Synthesis of 2-amino-s-triazino[1,2-a]benzimidazoles as potential antifolates from 2-guanidino- and 2-guanidino-5-methylbenzimidazoles
Dolzhenko, Anton V.,Chui, Wai-Keung
, p. 95 - 100 (2006)
The syntheses of 2-amino-s-triazino[1,2-a]benzimidazoles from 2-guanidinobenzimidazoles were successfully carried out by a ring annelation reaction. The regiochemistry of the ring closure of 5-methyl-2- guanidinobenzimidazole with diethyl azodicarboxylate, aldehydes, acetone, diethyl ethoxymethylene-malonate and orthoesters, leading to the formation of s-triazine ring was studied. High regioselectivity was not observed in any of these reactions. However, the synthesis of s-triazino[1,2-a]benzimidazole system was found to be more regioselective than its 3,4-dihydro analogue. NOESY experiment indicated that the compound, 2-amino-4,4-dimethyl-3,4-dihydro-s- triazino[1,2-a]benzimidazole existed predominantly as the 3,4-dihydro tautomer in dimethyl sulfoxide. It was found to inhibit bovine dihydrofolate reductase with IC50 10.9 μM.
Synthesis of novel fused pyrimidines and imidazoles as potential analgesics from 2-amino-4-substituted-striazino[1,2-a]-benzimidazoles
El-Feky, Said A.,Thabet, Hamdy Kh.,Mudawi, Mahmoud M. E.
, p. 709 - 718 (2015/10/28)
The synthesis of novel fused pyrimidines and imidazole derivatives from 2-amino-s-triazino[1,2-a]benzimidazoles 2a-e and 3a-c was successfully carried out by a ring annelation reaction in a very good yield. Compound 3c was screened for analgesic activity against acetic acid irritation and has shown protection equal to the reference drug (diclofenac sodium). The acute toxicity study revealed that compound 3c is safe up to 300 mg/kg and there is no sign and symptoms of toxicity and mortality for 72 hours.
Synthesis, crystal structure determination and antiproliferative activity of novel 2-amino-4-aryl-4,10-dihydro[1,3,5]triazino[1,2-a]benzimidazoles
Hranjec, Marijana,Pavlovi?, Gordana,Karminski-Zamola, Grace
experimental part, p. 242 - 251 (2012/03/08)
This manuscript describes the synthesis of novel 2-amino-4-aryl-4,10- dihydro-[1,3,5]triazino[1,2-a]benzimidazoles as hydrochloride salts 4a-n and 5b which were prepared in the reaction of cyclocondensation between 2-guanidinobenzimidazole and versatile h
SYNTHESIS OF SOME PYRIMIDO !1,6-!! BENZIMIDAZOLA DERIVATIVES
NAGARAJAN K,RANGA RAO V,VENKATESWARLU A
, p. 126 - 129 (2007/10/08)
The base-catalyzed condensation of 2- (!- aminoethyl) benzimidazole with a vareity of aldehydes, such as formaldehyde, benzaldehyde, p- chlorobenzaldehye, etc. , yields tetrahydropyrimido !1,6-!! benzimidazoles. The NMR spectral data of the products decidedly favor a cyclic structure as compared to the isomeric open chain Schiff's base.
