2697-71-4Relevant academic research and scientific papers
Transition-metal-free oxidative iodination of 1,3,4-oxadiazoles
Dannenberg, Carl Albrecht,Bizet, Vincent,Zou, Liang-Hua,Bolm, Carsten
, p. 77 - 80 (2015)
Transition-metal-free oxidative iodination of 2-substituted 1,3,4-oxadiazoles was achieved by using sodium iodide as the halide source and Selectfluor as the oxidant. Variously substituted products were obtained in moderate to good yields under operationa
Direct C-H iodination of 1,3-azoles catalysed by CuBr2
Zhao, Xia,Ding, Fang,Li, Jingyu,Lu, Kui,Lu, Xiaoyu,Wang, Bin,Yu, Peng
supporting information, p. 511 - 513 (2015/02/19)
A mild method was developed for the direct C-H iodination of 1,3-azoles catalysed by CuBr2. Compared with the traditional metalation/iodination sequences carried out with nBuLi or TMPLi (TMP = 2,2,6,6-tetramethylpiperidino), a relatively weaker base, LiOtBu, was used in the presence of 1,10-phenanthroline. Five series of 1,3-azoles, including benzoxazole, benzothiozole, N-methyl-benzoimidazole, 5-phenyloxazole and 2-phenyl-1,3,4-oxadiazole were tested and afforded the corresponding iodination products.
(tmp)2Zn·2 MgCl2·2 LiCl: A chemoselective base for the directed zincation of sensitive arenes and heteroarenes
Wunderlich, Stefan H.,Knochel, Paul
, p. 7685 - 7688 (2008/09/18)
(Chemical Equation Presented) Positive zincing: A wide range of polyfunctional aryl and heteroaryl zinc reagents were efficiently prepared in THF by direct zincation using (tmp)2Zn·2 MgCl 2·2 LiCl (1), an exceptionally active base. Ester and cyano functions as well as aldehydes and nitro groups are tolerated. dba = dibenzylideneacetone, tmp = 2,2,6,6-tetramethylpiperidide.
