825-56-9

Usage

Uses

Used in Organic Synthesis:
2-Phenyl-1,3,4-oxadiazole is used as a building block in organic synthesis for its ability to enhance the properties of other compounds, such as fluorescence, which is beneficial in the creation of advanced materials and chemical structures.
Used in Fluorescent Probes and Sensors:
Leveraging its fluorescent properties, 2-Phenyl-1,3,4-oxadiazole is used as a component in the development of fluorescent probes and sensors, which are essential tools in various analytical and diagnostic applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Phenyl-1,3,4-oxadiazole is utilized for its antimicrobial and anti-inflammatory properties, making it a promising candidate for the development of new drugs and treatments.
Used in Agrochemical Production:
2-Phenyl-1,3,4-oxadiazole serves as an intermediate in the production of various agrochemicals, contributing to the development of effective solutions for agricultural applications.
Overall, 2-Phenyl-1,3,4-oxadiazole is a multifaceted compound with applications spanning from organic synthesis to pharmaceutical and agrochemical development, highlighting its importance in the advancement of scientific and industrial fields.

InChI:InChI=1/C8H6N2O/c1-2-4-7(5-3-1)8-10-9-6-11-8/h1-6H

Upstream product

• 60-29-7 diethyl ether 
• 618-32-6 Benzoyl bromide 
• 67880-27-7 diazo-methane; diazomethyl lithium 
• 93-89-0 benzoic acid ethyl ester 
• 613-94-5 benzoic acid hydrazide 
• 122-51-0 orthoformic acid triethyl ester 
• 16691-25-1 ethyl 5-phenyl-1,3,4-oxadiazole-2-carboxylate 
• 59105-32-7 3-formyl-5-phenyl-3H-[1,2,3,4]oxathiadiazole 2-oxide 
• 1485-62-7 1,3,5-trisbenzamidohexahydrotriazine monohydrate 
• 288-94-8 1H-tetrazole 
• 93-97-0 benzoic acid anhydride 
• 149-73-5 trimethyl orthoformate 
• 73789-56-7 N-isocyaniminotriphenylphosphorane 
• 65-85-0 benzoic acid 

Downstream Products

• 4291-14-9 phenyl-1,3,4-thiadiazole 
• 5585-19-3 2-phenyl-1,3,4-thiadiazole-5(4H)-thione 
• 62487-37-0 furan-2-carboxylic acid furan-2-yl-bis-(5-phenyl-[1,3,4]oxadiazol-2-yl)-methyl ester 
• 62458-13-3 (furan-2-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone 
• 10283-95-1 N-allylbenzamide 
• 160455-79-8 4-allyl-3-phenyl-4H-1,2,4-triazole 
• 402598-99-6 4-(trans-2-butenyl)-3-phenyl-4H-1,2,4-triazole 
• 38345-23-2 4-amino-3-phenyl-1,2,4-triazole 
• 14331-64-7 3,4-diphenyl-1,2,4-triazole 
• 14331-67-0 4-(4-methylphenyl)-3-phenyl-4H-1,2,4-triazole 
• 660847-45-0 {1-[(R/S)-hydroxy-(5-phenyl-[1,3,4]oxadiazol-2-yl)-(S)-methyl]-3-methylbutyl}carbamic acid tert-butyl ester 
• 660847-58-5 (1-{1(R/S)-[hydroxy-(5-phenyl-[1,3,4]oxadiazol-2-yl)-(S)-methyl]-3-methylbutylcarbamoyl}-2-(S)-methoxyethyl)carbamic acid tert-butyl ester 
• 660847-71-2 N₄-(2,2-dimethylpropyl)-N₁-(1-{1-(R/S)-[hydroxy-(5-phenyl-[1,3,4]oxadiazol-2-yl)-(S)-methyl]-3-(S)-methylbutylcarbamoyl}-2-methoxyethyl)-2(S)-(toluene-4-sulfonylamino)succinamide 
• 2697-71-4 5-iodo-2-phenyl-[1,3,4]oxadiazole 

Relevant academic research and scientific papers

General α-Amino 1,3,4-Oxadiazole Synthesis via Late-Stage Reductive Functionalization of Tertiary Amides and Lactams**

An iridium-catalyzed reductive three-component coupling reaction for the synthesis of medicinally relevant α-amino 1,3,4-oxadiazoles from abundant tertiary amides or lactams, carboxylic acids, and (N-isocyanimino) triphenylphosphorane, is described. Proceeding under mild conditions using (3)2) and tetramethyldisiloxane to access the key reactive iminium ion intermediates, a broad range of α-amino 1,3,4-oxadiazole architectures were accessed from carboxylic acid feedstock coupling partners. Extension to α-amino heterodiazole synthesis was readily achieved by exchanging the carboxylic acid coupling partner for C-, S-, or N-centered Br?nsted acids, and provided rapid and modular access to these desirable, yet difficult-to-access, heterocycles. The high chemoselectivity of the catalytic reductive activation step allowed late-stage functionalization of 10 drug molecules, including the synthesis of heterodiazole-fused drug–drug conjugates.

Copper-Catalyzed Enantioconvergent Cross-Coupling of Racemic Alkyl Bromides with Azole C(sp2)?H Bonds

The development of enantioconvergent cross-coupling of racemic alkyl halides directly with heteroarene C(sp2)?H bonds has been impeded by the use of a base at elevated temperature that leads to racemization. We herein report a copper(I)/cinchona-alkaloid-derived N,N,P-ligand catalytic system that enables oxidative addition with racemic alkyl bromides under mild conditions. Thus, coupling with azole C(sp2)?H bonds has been achieved in high enantioselectivity, affording a number of potentially useful α-chiral alkylated azoles, such as 1,3,4-oxadiazoles, oxazoles, and benzo[d]oxazoles as well as 1,3,4-triazoles, for drug discovery. Mechanistic experiments indicated facile deprotonation of an azole C(sp2)?H bond and the involvement of alkyl radical species under the reaction conditions.

COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING THE SAME

The present specification provides a compound represented by chemical formula 1 and an organic light emitting device including the same. The compound may improve lifespan characteristics of the organic light emitting device.

[4u202f+u202f1] Cyclization of benzohydrazide and ClCF2COONa towards 1,3,4-oxadiazoles and 1,3,4-oxadiazoles-d5

A facile synthesis of 1,3,4-oxadiazoles and 1,3,4-oxadiazoles-d5 via [4 + 1] cyclization of ClCF2COONa with non-amine compounds containing amino groups is developed. Of note, this is the first time that halofluorinated compounds are used as C1 synthon to construct deuterated nitrogen-heterocyclic compounds. The current protocol features simple operation, readily accessible raw materials, wide substrate scope and valuable products

Ligand-Enabled Palladium-Catalyzed Through-Space C?H Bond Activation via a Carbopalladation/1,4-Pd Migration/C?H Functionalization Sequence

We report, herein, a palladium-catalyzed cascade comprising carbopalladation, 1,4-Pd-migration and C(sp2)?C(sp2) bond formation to construct a variety of bis-heterocyclic frameworks in a single operational step. The methodology provi

Functionalization of 1,3,4-Oxadiazoles and 1,2,4-Triazoles via Selective Zincation or Magnesiation Using 2,2,6,6-Tetramethylpiperidyl Bases

We report the metalation of the 1,3,4-oxadiazole and 1,2,4-triazole scaffolds via regioselective zincation or magnesiation using the TMP bases (TMP = 2,2,6,6-tetramethylpiperidyl) TMP2Zn·2LiCl, TMP2Zn·2MgCl2·2LiCl, TMPMgCl

TiCl4 mediated facile synthesis of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles

An efficient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles has been developed. Various hydrazides or thionyl hydrazides readily react with DMA derivatives in the presence of TiCl4 as a catalyst to afford the desired products. This protocol provides a simple and economical procedure that affords the target products with good yields and wide substrate scope.

MONITORING AND DOSAGE CONTROL OF TAGGED TREATMENT POLYMERS IN INDUSTRIAL WATER SYSTEMS

The present invention relates to a fluorescently-tagged (co)polymer useful as a scale inhibitor in industrial water systems. Said (co)polymer comprises a (i) reactive fluorescent compound selected from a diazole compound (ii) at least one monoethylenicall

TAGGED TREATMENT POLYMERS FOR MONITORING ANTISCALANT CONCENTRATIONS IN INDUSTRIAL WATER SYSTEMS

The present invention relates to a fluorescently-tagged (co)polymer useful as a scale inhibitor in industrial water systems. Said (co)polymer comprises a (i) reactive fluorescent compound selected from a diazole compound (ii) at least one monoethylenicall

Two platinum(ii) complexes with a 4-phenyl-4: H -1,2,4-triazole derivative as an ancillary ligand for efficient green OLEDs

Two new cyclometalated platinum(ii) complexes ((TN3T)Pt(dptp), (4tfmppy)Pt(dptp)) with 2′,6′-bis(trifluoromethyl)-2,3′-bipyridine (TN3T) and 4-trifluoromethylphenylpyridine (4tfmppy) as the cyclometalated ligands and the nitrogen het