26971-99-3

Upstream product

• 59849-18-2 1-(4-chloro-benzoyl)-3-phenyl-thiourea 
• 103-71-9 phenyl isocyanate 
• 619-56-7 4-chlorobenzamide 
• 122-01-0 4-chloro-benzoyl chloride 
• 95-14-7 1,2,3-Benzotriazole 
• 55-21-0 benzamide 
• 4231-70-3 p-chlorobenzoyl-1H-1,2,3-benzotriazole 
• 21368-28-5 4-chlorobenzoyl azide 
• 201230-82-2 carbon monoxide 
• 62-53-3 aniline 
• 104417-74-5 1,1-Bis-(4-chloro-benzoyl)-3,3-dimethyl-urea 
• 64-10-8 phenyl carbamate 
• 107820-30-4 1-hexen-2-yl 4-chlorobenzoate 
• 4461-36-3 4-chlorobenzoyl isocyanate 

Downstream Products

• 102-07-8 bis(diphenyl)urea 

Relevant academic research and scientific papers

N -Acylbenzotriazoles as Proficient Substrates for an Easy Access to Ureas, Acylureas, Carbamates, and Thiocarbamates via Curtius Rearrangement Using Diphenylphosphoryl Azide (DPPA) as Azide Donor

A diverse range of ureas, N -acylureas, carbamates, and thiocarbamates has been synthesized in good to excellent yields by reacting N -acylbenzotriazoles individually with amines or amides or phenols or thiols in the presence of diphenylphosphoryl azide (DPPA) as a suitable azide donor in anhydrous toluene at 110 °C for 3-4 hours. In this route, DPPA was found to be a good alternative to trimethylsilyl azide and sodium azide for the azide donor in Curtius degradation. The high reaction yields, one-pot and metal-free conditions, straightforward nature, easy handling, use of readily available reagents, and in many cases avoidance of column chromatography are the notable features of the devised protocol.

Pd-Catalyzed Carbonylation of Acyl Azides

Pd-catalyzed reactions of azides with CO to access an isocynate intermediate have been developed extensively in recent years. However, the catalytic carbonylation of sensitive acyl azides has not been reported. Herein, we report a simple Pd-catalyzed carbonylation reaction of acyl azides with broad substrate scope, high efficiency, and simple operation under mild conditions, which provides facile access to acyl ureas. In addition, a mechanistic study was carried out by both experiment and DFT calculation. Control experiments and kinetic study revealed that the real active palladium species were Pd(0). The result of kinetic study suggested that palladium catalyst, azide, and CO were all involved in the turnover-limiting step except for amine. Further DFT study suggested that an unprecedented five-membered palladacycle intermediate was the key intermediate in the carbonylation reaction. ?

Efficient Preparations of Acylamides, Acylcarbamates and Acylureas from Alk-1-en-2-yl Esters

Acylamides, acylcarbamates and acylureas have been synthesized by acylation of amides, carbamates and ureas sodium salts with alk-1-en-2-yl esters prepared with 2 as catalyst.

CONDENSATION OF ACYL CHLORIDE ON SODIUM CYANATE : PREPARATION OF ACYL ISOCYANATES

The catalytic effects of various metal halides and solvents on the reaction of benzoyl chloride with sodium cyanate were studied.It has been found that SnCl4, and ZnCl2 catalyze the reaction to give the corresponding acyl isocyanates in good yields.The scope of the reaction was studied and a number of aroyl isocyanates and their derivatives were prepared.A few non aromatic isocyanates and their derivatives were also prepared.

REACTION OF N-ACYLTHIOUREAS WITH ELECTROPHILIC REAGENTS SYNTHESIS OF 1,3,5-OXADIAZINIUM SALTS, 1,2,4-DITHIAZOLIUM SALTS AND BENZOTHIAZOLES

N-Acylthioureas 1 can be easily transformed into 2,4-diamino-6-aryl-1,3,5-oxadiazinium salts 12, 2,4-diamino-6-aryl-1,3,5-thiadiazinium salts 13, 3-amino-5-aryl-1,2,4-dithiazolium salts 19 and 2-acylimino-benzothiazolines 22, respectively by reaction with