269731-79-5

Upstream product

• 220772-30-5 1-(tert-butoxycarbonyl)-4-(3,4-dichloro-benzylidene)piperidine 
• 645379-16-4 1,1-dimethylethyl-4-[(3,4-dichlorophenyl)(hydroxy)methyl]-1-piperidinecarboxylate 

Downstream Products

• 269731-80-8 (3,4-dichloro-phenyl)-piperidin-4-yl-methanone 
• 645379-18-6 1,1-dimethylethyl-4-[(3,4-dichlorophenyl)carbonyl]-4-fluoro-1-piperidinecarboxylate 

Relevant academic research and scientific papers

Aromatic cycloamines derivative and application in multi-target antidepressant medicine

The invention discloses an aromatic cycloamines derivative and an application in multi-target antidepressant medicine. The aromatic cycloamines derivative has inhibitory activity on 5-HT reuptake, NEreuptake and DA reuptake, is a novel compound of a 5-HT/

N-BENZYL-3-PHENYL-3-HETEROCYCLYL-PROPIONAMIDE COMPOUNDS AS TACHYKININ AND/ OR SEROTONIN REUPTAKE INHIBITORS

The present invention relates to heterocyclic derivatives of formula (1) wherein R1 represents a 5 or 6 membered heteroaryl group, in which the 5-membered heteroaryl group contains at least one heteroatom selected from oxygen, sulphur or nitrogen and the 6-membered heteroaryl group contains from 1 to 3 nitrogen atoms, or R1 represents a 4,5 or 6 membered heterocyclic group, wherein saids 5 or 6 membered heteroaryl or the 4,5 or 6 membered heterocyclic group may optionally be substituted by one to three substituents, which may be the same or different, selected from (CH2)pR6, wherein p is zero or an integer from 1 to 4 and wherein R and R2- R6 are each as defined in the description and pharmaceutically acceptable salts and solvates thereof; process for their preparation and their use in the treatment of conditions mediated by tachykinins and/or by selective inhibition of serotonin reuptake transporter protein.

4-AROYL-PIPERIDIN-CCR-3 RECEPTOR ANTAGONISTS III

This invention relates to certain piperidine quaternary salts of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

4-aroylpiperidine derivatives-CCR-3 receptor antagonists

This invention relates to certain piperidine quaternary salts of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.