26974-74-3

Upstream product

• 625-36-5 2-chloropropionyl chloride 
• 6315-89-5 3,4-dimethoxyaniline 

Downstream Products

• 113241-43-3 N-(3,4-dimethoxyphenyl)-3-<<2-(3,4-dimethoxyphenyl)ethyl>methylamino>propanamide 
• 113241-38-6 N-(3,4-dimethoxyphenyl)-N'-[2-(3,4-dimethoxyphenyl)-ethyl]-N'-methyl-1,3-propanediamine 
• 113241-09-1 (N-(3,4-dimethoxyphenyl)-N-3-(N'-2-(3,4-dimethoxyphenyl)-ethyl-N'-methyl-amino)-propyl)-N'-4-nitrobenzamide hydrochloride 

Relevant academic research and scientific papers

Imidazopyridine- and purine-thioacetamide derivatives: Potent inhibitors of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1)

Nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) belongs to the family of ecto-nucleotidases, which control extracellular nucleotide, nucleoside, and (di)phosphate levels. To study the (patho)physiological roles of NPP1 potent and selective inhibitors with drug-like properties are required. Therefore, a compound library was screened for NPP1 inhibitors using a colorimetric assay with p-nitrophenyl 5′-thymidine monophosphate (p-Nph-5′-TMP) as an artificial substrate. This led to the discovery of 2-(3H-imidazo[4,5-b]pyridin-2-ylthio)-N-(3,4-dimethoxyphenyl)acetamide (5a) as a hit compound with a Ki value of 217 nM. Subsequent structure-activity relationship studies led to the development of purine and imidazo[4,5-b]pyridine analogues with high inhibitory potency (Ki values of 5.00 nM and 29.6 nM, respectively) when assayed with p-Nph-5′-TMP as a substrate. Surprisingly, the compounds were significantly less potent when tested versus ATP as a substrate, with Ki values in the low micromolar range. A prototypic inhibitor was investigated for its mechanism of inhibition and found to be competitive versus both substrates.

Synthesis, electrophysiological properties and analysis of structural requirements of a novel class of antiarrhythmic agents with potassium and calcium channel blocking properties

Class III antiarrhythmic agents have been shown to prevent reentrant arrhythmias but also to be responsible for initiating arrhythmias characterised by afterdepolarizations and triggered activities. By combining potassium and calcium channel antagonistic

Herbicidal N-aryl substituted azetidinones

Disclosed are herbicidal compositions comprising an inert carrier and as an essential active ingredient in a quantity toxic to weeds a compound of the formula EQU1 wherein X is selected from the group consisting of alkyl, alkenyl, alkoxy, alkylthio, halogen, haloalkyl and nitro; and n is an integer from 0 to 5.