26976-83-0Relevant academic research and scientific papers
3(2H)-furanones promising candidates for synthesis of new fluorescent organic probes
Soliman, Mohamed H. A.,Hussein, Belal H. M.,Abdel-Moati, Nahla,El-Tamany, El-Sayed H. M.
, p. 567 - 575 (2019/05/21)
Several novel 3-arylidene-5-(4-memoxy-3-nitrophenyl)-2(3H)-furanones (2a-d) have been successfully prepared and used as precursors for building up of other new heterocyclic architectures such as pyrrolones (4a-c), (5) and unsaturated aroyl-hydrazides (7a-d). These aroyl-hydrazides have been subsequently converted into pyridazinone derivatives (8a-d) by refluxing in HCl/AcOH mixture. Eventually, benzoylation of the hydrazides (7a-c) with benzoyl chloride affords the corresponding N-benzoyl-3(2H)-pyridazinones (9a-c). The structures of all synthesized compounds have been established using elemental analysis and spectral methods. The photophysical (fluorescence and electronic absorption spectra) properties of newly synthesized compounds have also been investigated.
4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity
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, (2008/06/13)
4-phenyl-4-oxo-butanoic acid derivatives for use in the treatment of the human or animal body by therepy; particularly as kynurenine-3-hydroxylase inhibitors, in the prevention and/or treatment of a neurodegenerative disease wherein the inhibition of such an enyzme is needed. The present invention further comprises a selected class of the above mentioned 4-phenyl-4-oxo-butanoic acid derivatives, their pharmaceutically acceptable salts, a process for their preparation and pharmaceutical compositions containing them.
