27004-49-5

Basic information

• Product Name: hydroxy(1H-indol-3-yl)acetic acid
• CAS NO: 27004-49-5
• Molecular Formula: C₁₀H₉NO₃
• Molecular Weight: 191.1834
• Mol File: 27004-49-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 478.5°C at 760 mmHg
• Flash Point: 243.2°C
• Density: 1.498g/cm³
• Vapor Pressure: 5.76E-10mmHg at 25°C
• Refractive Index: 1.734
• CAS DataBase Reference: hydroxy(1H-indol-3-yl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: hydroxy(1H-indol-3-yl)acetic acid(27004-49-5)
• EPA Substance Registry System: hydroxy(1H-indol-3-yl)acetic acid(27004-49-5)

Safety Data

• Hazardous Substances Data: 27004-49-5(Hazardous Substances Data)

Upstream product

• 120-72-9 indole 

Relevant articles and documents

Bioconjugation with Thiols by Benzylic Substitution

A benzylic substitution of 3-indolyl(hydroxyl)acetate derivatives with thiols proceeded specifically in the presence of amino, carboxy, and phosphate groups in weakly acidic aqueous solutions under nearly physiological condition, while no reaction occurred at pH over 7. Kinetic studies revealed that the reaction followed second-order kinetics (first-order in the reactant and first-order in thiol) in contrast with the SN1 mechanism of common benzylic substitution of alcohols. The utility of the present method for functionalization of biomacromolecules was demonstrated using several model proteins, such as lysozyme, insulin, trypsin, and serum albumin. The catalytic bioactivity of lysozyme in lysis of Micrococcus lysodeikticus cells was completely retained after the modification.