27006-86-6Relevant academic research and scientific papers
Synthesis and bioactivities of novel pyrazole oxime derivatives containing a 1,2,3-thiadiazole moiety
Dai, Hong,Ge, Shushan,Li, Gang,Chen, Jia,Shi, Yujun,Ye, Linyu,Ling, Yong
supporting information, p. 4504 - 4507 (2016/08/25)
A series of new pyrazole oxime compounds bearing a 1,2,3-thiadiazole ring were designed, synthesized, and evaluated for their insecticidal, acaricidal and antitumor activities. Bioassays demonstrated that some title compounds displayed satisfactory insecticidal and acaricidal properties. Especially, compounds 8d and 8h exhibited 90% insecticidal activities against Aphis craccivora at the concentration of 100?μg/mL. Interestingly, some of the target compounds possessed significant antitumor activities against four human cancer cell lines in vitro. Among them, compounds 8e (IC50?=?7.19?μM), 8l (IC50?=?6.56?μM), 8m (IC50?=?8.12?μM), and 8r (IC50?=?7.06?μM) had better inhibitory activities against HCT-116 cells than the control 5-fluorouracil (IC50?=?29.50?μM). Additionally, compounds 8j, 8m, and 8r showed wonderful inhibitory activities against SGC-7901 cells with the IC50values of 11.46, 9.41, and 8.64?μM, respectively, which were superior to that of the control 5-fluorouracil.
SUBSTITUTED BENZENE AND 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS
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Paragraph 0519; 0525-0523, (2016/05/02)
The present invention relates to substituted benzene compounds and bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
GROUP DIPOLE MOMENTS OF SUBSTITUENTS AT POSITIONS 4 AND 5 OF NITROGEN-CONTAINING FIVE-MEMBERED HETEROCYCLES
Fradkina, S. P.,Kvitko, I. Ya.,Alam, L. V.,Fedorova, N. S.
, p. 191 - 196 (2007/10/02)
The dipole moments of the 5-chloro-4-cyano derivatives of oxazole, thiazole, imidazole, and pyrazole were determined.The group dipole moments of substituents at positions 2 and 3 of furan, thiophene, and pyrrole can be used for vector calculation of the dipole moments of various 4- and 5-substituted azoles.
