270076-41-0Relevant academic research and scientific papers
Expanding substrate scope of lipase-catalyzed transesterification by the utilization of liquid carbon dioxide
Hoang, Hai Nam,Matsuda, Tomoko
, p. 7229 - 7234 (2016)
Secondary alcohols having bulky substituents on both sides of the chiral center are often poor substrates for most lipases. Here we reported that substrate scopes of two of the most used lipases, Candida antarctica lipase B and Burkholderia cepacia lipase, were found to be expanded toward more bulky secondary alcohols such as 1-phenyl-1-dodecanol and 2-methyl-1-phenyl-1-propanol by simply using them in liquid carbon dioxide as a solvent. The effects of solvents, reaction pressure, and pre-treatment of the enzyme with liquid CO2on this acceleration phenomenon were also studied.
Iron achieves noble metal reactivity and selectivity: Highly reactive and enantioselective iron complexes as catalysts in the hydrosilylation of ketones
Bleith, Tim,Wadepohl, Hubert,Gade, Lutz H.
supporting information, p. 2456 - 2459 (2015/03/04)
Chiral iron alkyl and iron alkoxide complexes bearing boxmi pincers as stereodirecting ligands have been employed as catalysts for enantioselective hydrosilylation reactions with unprecedented activity and selectivity (TOF = 240 h-1 at -40 °C, ee up to 99% for alkyl aryl ketones), which match the performance of previously established noble-metal-based catalysts. This shows the potential of earth-abundant metals such as iron for replacing platinum-metals without any drawbacks for the reaction design.
Asymmetric synthesis of new chiral long chain alcohols
Yildiz, Tuelay,Yusufolu, Aye
experimental part, p. 2981 - 2987 (2011/03/20)
Sixteen new chiral alcohols with alkyl (C11-C19) and aryl, substituted aryl, hetero aryl and biaryl groups 2a-2t were synthesized by three different asymmetric reduction methods from their corresponding ketones 1a-1t. Chiral NaBHsub
