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270082-22-9

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270082-22-9 Usage

Uses

It is used as an active pharmaceutical intermediate. It is also an important organic intermediate used in agrochemicals, pharmaceuticals and dyestuff fields.

Check Digit Verification of cas no

The CAS Registry Mumber 270082-22-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,7,0,0,8 and 2 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 270082-22:
(8*2)+(7*7)+(6*0)+(5*0)+(4*8)+(3*2)+(2*2)+(1*2)=109
109 % 10 = 9
So 270082-22-9 is a valid CAS Registry Number.
InChI:InChI=1/C11H13NO2.ClH/c13-11(14)6-10-5-8-3-1-2-4-9(8)7-12-10;/h1-4,10,12H,5-7H2,(H,13,14);1H/t10-;/m0./s1

270082-22-9 Well-known Company Product Price

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  • Alfa Aesar

  • (H52111)  (S)-1,2,3,4-Tetrahydroisoquinoline-3-acetic acid hydrochloride, 95%   

  • 270082-22-9

  • 250mg

  • 2058.0CNY

  • Detail
  • Alfa Aesar

  • (H52111)  (S)-1,2,3,4-Tetrahydroisoquinoline-3-acetic acid hydrochloride, 95%   

  • 270082-22-9

  • 1g

  • 6174.0CNY

  • Detail

270082-22-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-2-TETRAHYDROISOQUINOLINE ACETIC ACID HYDROCHLORIDE

1.2 Other means of identification

Product number -
Other names (S)-2-tetrahydroisoquinolineaceticacidCl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:270082-22-9 SDS

270082-22-9Downstream Products

270082-22-9Relevant articles and documents

1-BENZYLSPIRO[PIPERIDINE-4,1′-PYRIDO[3,4-b]indole] ‘co-potentiators’ for minimal function CFTR mutants

Son, Jung-Ho,Phuan, Puay-Wah,Zhu, Jie S.,Lipman, Elena,Cheung, Amy,Tsui, Ka Yi,Tantillo, Dean J.,Verkman, Alan S.,Haggie, Peter M.,Kurth, Mark J.

, (2020/10/26)

We previously identified a spiro [piperidine-4,1-pyrido [3,4-b]indole] class of co-potentiators that function in synergy with existing CFTR potentiators such as VX-770 or GLGP1837 to restore channel activity of a defined subset of minimal function cystic fibrosis transmembrane conductance regulator (CFTR) mutants. Here, structure-activity studies were conducted to improve their potency over the previously identified compound, 20 (originally termed CP-A01). Targeted synthesis of 37 spiro [piperidine-4,1-pyrido [3,4-b]indoles] was generally accomplished using versatile two or three step reaction protocols with each step having high efficiency. Structure-activity relationship studies established that analog 2i, with 6′-methoxyindole and 2,4,5-trifluorobenzyl substituents, had the greatest potency for activation of N1303K-CFTR, with EC50 ~600 nM representing an ~17-fold improvement over the original compound identified in a small molecule screen.

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