27022-75-9Relevant academic research and scientific papers
Solvent hydrogen bonding and structural effects on nucleophilic substitution reactions: Part 3. Reaction of benzenesulfonyl chloride with anilines in benzene/ propan-2-ol mixtures
Bhuvaneshwari,Elango
, p. 657 - 663 (2007)
Substitution reactions of 13 para- and meta-substituted anilines with benzene-sulfonyl chloride in varying mole fractions of benzene in propan-2-ol have been investigated conductometrically, The second-order rate constants correlate well with pKa values of anilines and with the Hammett's equation. The negative Hammett reaction constant indicates the formation of an electron-deficient transition state. The rate data correlate satisfactorily with macroscopic solvent parameters such as relative permittivity, εr, and polarity, ETN. Correlation of rate data with Kamlet-Taft solvatochromic parameters (α, β, π*) suggests that both the specific and nonspecific solute-solvent interactions influence the reactivity.
Solvent hydrogen bonding and structural effects on nucleophilic aromatic substitution reactions. Part-2: Reaction of benzenesulphonyl chloride with anilines in propan-2-ol/2-methylpropan-2-ol mixtures
Bhuvaneshwari,Elango
experimental part, p. 233 - 241 (2010/04/05)
Substitution reactions of fourteen para- and meta-substituted anilines with benzenesulphonyl chloride in different mole fractions of propan-2-ol in 2-methylpropan-2-ol have been investigated conductometrically. The second order rate constants correlates satisfactorily with pKa values of the anilines and also with the Hammett's substituent constant. The para-substituted anilines shows a satisfactory correlation with Charton's LDR equation. The results of these correlations indicate the formation of an electron deficient transition state. The rate data correlate satisfactorily with macroscopic solvent parameters such as relative permittivity, εr and polarity, ETN. Multiple correlation analysis of the rate data via Kamlet-Taft's solvatochromic parameters reveals that the solvent dipolarityfpolarizability plays a dominant role in governing the reactivity.
Solvent hydrogen bonding and structural effects on nucleophilic substitution reactions. Part-1: Reaction of benzenesulphonyl chloride with anilines in benzene/2-methylpropan-2-ol-mixtures
Bhuvaneshwari,Elango
experimental part, p. 1227 - 1233 (2009/12/31)
Substitution reactions of eleven para- and meta-substitutcd anilines with benzencsulphonyl chloride in different mole fractions of benzene in 2-methylpropan-2-ol have been investigated conductometrically. The second order rate constants don't correlate either with pK values of the anilines or with the Hammett's and its modified equations. The para-substituted anilines shows a satisfactory correlation with Charton's LDR equation and the results indicate the formation of an electron deficient transition state. The rate data correlate satisfactorily with macroscopic solvent parameters such as relative permittivity, εr, and polarity, ETN. Multiple correlation analysis of the rate data via Kamlet-Taft's solvatochromic parameters reveals that the solvent hydrogen bond donor property plays a dominant role in governing the reactivity.
Preparation of Nonsymmetrical p-Benzoquinone Diimines for Evaluation as Protein Cleavage Reagents
Holmes, Thomas J.,Lawton, Richard G.
, p. 3146 - 3150 (2007/10/02)
In an effort to improve the yield, selectivity, and mildness of reaction conditions employed in protein cleavage with bisalkylating quinone diimines, a series of analogous reagents (1a-h) were prepared.These novel N1,N4 nonsymmetrica
