270253-11-7Relevant academic research and scientific papers
Trifluoromethyl-modified dipeptides by ZrCl4-promoted aza-Henry reactions
Fioravanti, Stefania,Pelagalli, Alessia,Pellacani, Lucio,Sciubba, Fabio,Vergari, Maria Cecilia
, p. 1961 - 1970 (2014)
Chiral (R)-1-phenylethylamine was successfully employed in a tandem aza-Henry addition-reduction reaction to give chiral β-nitro α-trifluoromethyl amines. A subsequent coupling reaction with N-Boc-protected amino acids leads to obtain optically pure CF s
Fluorinated β-nitro amines by a selective ZrCl4-catalyzed aza-Henry reaction of (E)-trifluoromethyl aldimines
Fioravanti, Stefania,Pellacani, Lucio,Vergari, Maria Cecilia
supporting information, p. 8207 - 8210,4 (2012/12/12)
ZrCl4 was found to be an ideal catalyst to promote aza-Henry reactions between trifluoromethyl aldimines and some nitro alkanes giving new fluorinated β-nitro amines. The reaction is strongly influenced by the CF3 group, the yield by
N-Substituted α-trifluoromethyl β-nitro amines in the synthesis of fluorine-containing 1,2-diamines, amino alcohols, and β-amino acids
Korotaev,Barkov,Kodess,Kutyashev,Slepukhin,Zapevalov
, p. 1886 - 1898 (2011/01/08)
Reactions of 2-diazo-1,1,1-trifluoro-3-nitropropane or 1-trifluoromethyl-2- nitroethenes with amines and amino alcohols afforded N-mono- and N,N-disubstituted α-trifluoromethyl β-nitro amines, which were used to obtain a number of trifluoromethyl-containing 1,2-diamines, amino alcohols, and β-amino acids.
Novel 1-trifluoromethyl substituted 1,2-ethylenediamines and their use for the synthesis of fluoroquinolones
Aizikovich, Alexander Ya.,Nikonov, Maxim V.,Kodess, Michael I.,Korotayev, Vladislav Yu.,Charushin, Valery N.,Chupakhin, Oleg N.
, p. 1923 - 1927 (2007/10/03)
A common approach to the synthesis of 1-trifluoromethyl-1,2- ethylenediamines was developed. Based on these original building blocks the new derivatives of N-substituted fluoroquinolones bearing the trifluoromethyl group were obtained. Through-space transmitted coupling constants 7J(F-F) between the trifluoromethyl group and F-8 were measured in the 19F NMR spectra of all fluoroquinolones examined and assigned unequivocally by using 19F{19F} double resonance technique. (C) 2000 Elsevier Science Ltd.
Synthesis of 1-polyfluoroalkyl-1,2-diamines
Aizikovich,Korotaev
, p. 207 - 208 (2007/10/03)
Reduction of 1-amino-2-nitro-1-polyfluoroalkylethylenes and 2-(N-benzoyl)amino-3-nitro-1,1,1-trifluoropropane with lithium aluminum hydride results in 1-polyfluoroalkyl-1,2-diamines.
