270260-56-5

Basic information

• Product Name: Carbamic acid, [[4-[(phenylsulfonyl)amino]phenyl]methyl]-, 1,1-dimethylethyl ester
• CAS NO: 270260-56-5
• Molecular Formula: C18H22N2O4S
• Molecular Weight: 362.45
• Mol File: 270260-56-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [[4-[(phenylsulfonyl)amino]phenyl]methyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [[4-[(phenylsulfonyl)amino]phenyl]methyl]-, 1,1-dimethylethyl ester(270260-56-5)
• EPA Substance Registry System: Carbamic acid, [[4-[(phenylsulfonyl)amino]phenyl]methyl]-, 1,1-dimethylethyl ester(270260-56-5)

Safety Data

• Hazardous Substances Data: 270260-56-5(Hazardous Substances Data)

Upstream product

• 4403-71-8 (4-aminomethyl)aniline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 98-09-9 benzenesulfonyl chloride 
• 94838-55-8 tert-butyl (4-aminobenzyl)carbamate 

Relevant articles and documents

Small-Molecule Inhibitors Targeting Sterol 14α-Demethylase (CYP51): Synthesis, Molecular Modelling and Evaluation Against Candida albicans

Fungal infections are a global issue affecting over 150 million people worldwide annually, with 750 000 of these caused by invasive Candida infections. Azole drugs are the frontline treatment against fungal infections; however, resistance to current azole

N-(3-acyloxy-2-benzylpropyl)-N′-[4-(methylsulfonylamino)benzyl]thiourea analogues: Novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor

Isosteric replacement of the phenolic hydroxyl group in potent vanilloid receptor (VR1) agonists with the alkylsulfonamido group provides a series of compounds which are effective antagonists to the action of the capsaicin on rat VR1 heterologously expressed in Chinese hamster ovary (CHO) cells. In particular, compound 61, N-[2-(3,4-dimethylbenzyl)-3-pivaloyloxypropyl]-N′-[3-fluoro-4- (methylsulfonylamino)benzyl]thiourea was a full antagonist against capsaicin, displayed a Ki value of 7.8 nM (compared to 520 nM for capsazepine and 4 nM for 5-iodoRTX), and showed excellent analgesic activity in mice. Structure-activity analysis of the influence of modifications in the A- and C-regions of 4-methylsulfonamide ligands on VR1 agonism/antagonism indicated that 3-fluoro substitution in the A-region and a 4-tert-butylbenzyl moiety in the C-region favored antagonism, whereas a 3-methoxy group in the A-region and 3-acyloxy2-benzylpropyl moieties in the C-region favored agonism.