27046-49-7Relevant academic research and scientific papers
Derivatives of 11-(1-Piperazinyl)-5H-pyrrolobenzodiazepine as Central Nervous System Agents
Wright, William B.,Greenblatt, Eugene N.,Day, Ivana P.,Quinones, Nicanor Q.,Hardy, Robert A.
, p. 462 - 465 (2007/10/02)
Four 11-(1-piperazinyl)5H-pyrrolobenzodiazepines were prepared and evaluated as central nervous system agents.All were active psychotropic agents as determined by animal screening tests.The most interesting compound, 11-(1-piperazinyl)-5H-pyrrolobenzodiazepine, showed dual activity as an antidepressant against tetrabenazine depression and as a neuroleptic as measured by protection vs. amphetamine lethality in grouped mice.
