27053-25-4Relevant academic research and scientific papers
Synthesis and BK channel-opening activity of 2-amino-1,3-thiazole derivatives
Cui, Yong-Mei,Ji, Tong-Tong,Jo, Heeji,Lin, Hai-Xia,Park, Chul-Seung,Qi, Xiao-Lei,Wang, Xue-Ying
supporting information, (2021/05/19)
A series of 2-amino-5-arylmethyl- or 5-heteroarylmethyl-1,3-thiazole derivatives were synthesized and evaluated for BK channel-opening activities in cell-based fluorescence assay and electrophysiological recording. The assay results indicated that the activities of the investigated compounds were influenced by the physicochemical properties of the substituent at benzene ring.
Synthesis of 2-Amino-5-acylthiazoles by a Tertiary Amine-Promoted One-Pot Three-Component Cascade Cyclization Using Elemental Sulfur as a Sulfur Source
Fu, Rong-Geng,Wang, Yong,Xia, Fei,Zhang, Hao-Lin,Sun, Yuan,Yang, Duo-Wen,Wang, Ye-Wei,Yin, Peng
, p. 12237 - 12245 (2019/10/11)
A novel one-pot three-component cascade cyclization strategy for the synthesis of 2-amino-5-acylthiazoles using enaminones, cyanamide, and elemental sulfur has been developed. The reported methods have demonstrated good tolerance of various functional gro
2-Amino-5-acyl thiazole derivative and synthesis method thereof
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Paragraph 0050-0051; 0053; 0116, (2019/10/01)
The invention relates to a technology for synthesis of organic compounds and discloses a 2-amino-5-acyl thiazole derivative and a synthesis method thereof. The structure of the 2-amino-5-acyl thiazolederivative is shown in a formula (I), and R in the form
2-amino-4-dimethylamino-1-thia-3-azabutadienes as precursors of thiazoles
Landreau,Deniaud,Reliquet,Meslin
, p. 2651 - 2659 (2007/10/03)
The reaction of 2-amino-4-dimethylamino-1-thia-3-azabutadienes 1 with α-bromoketones gave rise to 2-aminothiazoles 2 together with 2-(N,N-dimethylaminomethylenamino)thiazoles 3. Competitive mechanisms are described. Furthermore, reaction of diene 1a with
