528818-71-5

Upstream product

• 99-73-0 para-bromophenacyl bromide 
• 121876-98-0 1,3-Bis-[1-dimethylamino-meth-(E)-ylidene]-thiourea 
• 96818-59-6 N,N'-bis[(dimethylamino)methylene]thiourea 

Downstream Products

• 1384188-43-5 3-(p-bromobenzoyl)-5-(1,2-O-isopropylidene-3-O-p-methoxybenzyl-α-D-xylofuranos-5-ulo-5-yl)imidazo[2,1-b]thiazole 
• 27053-25-4 (2-aminothiazol-5-yl)(4-bromophenyl)methanone 
• 1384188-41-3 3-(p-bromobenzoyl)-5-(1,2-O-isopropylidene-3-O-tert-butyldimethylsilyl-α-D-xylofuranos-5-ulo-5-yl)imidazo[2,1-b]thiazole 

Relevant academic research and scientific papers

Synthesis and BK channel-opening activity of 2-amino-1,3-thiazole derivatives

A series of 2-amino-5-arylmethyl- or 5-heteroarylmethyl-1,3-thiazole derivatives were synthesized and evaluated for BK channel-opening activities in cell-based fluorescence assay and electrophysiological recording. The assay results indicated that the activities of the investigated compounds were influenced by the physicochemical properties of the substituent at benzene ring.

From thiourea to bicyclic structures: An original route to imidazo[2,1-b]thiazoles, 5H-thiazolo[3,2-a]pyrimidines, 7H-imidazo[2,1-b][1,3]thiazines, and 2H,6H-pyrimido[2,1-b][1,3]thiazines

We report an example of an efficient regioselective synthesis of biheterocyclic compounds using thiourea as starting material. In fact, N,N′-bis(dimethylaminomethylene)thiourea (1), easily prepared by double condensation of N,N-dimethylformamide dimethyl acetal with thiourea, can be reacted with haloketones or acrylic dienophiles to give thiazolic (2) and thiazinic (3) diazadienes, respectively, themselves undergoing cyclization reactions to yield imidazo[2,1-b]thiazoles, 5H-thiazolo[3,2-a]pyrimidines, 7H-imidazo[2,1-b][1,3]thiazines, and 2H,6H-pyrimido[2,1-b][1,3]thiazines without any regioisomeric ambiguity. This straightforward route represents an original and unambiguously regioselective pathway to these valuable heterocycles.