270574-10-2

Upstream product

• 74960-43-3 3-methyl-2-phenyl-quinoline-4-carboxylic acid methyl ester 
• 174636-71-6 3-methyl-2-phenylquinoline-4-carbonyl chloride 
• 43071-45-0 3-methyl-2-phenylquinoline-4-carboxylic acid 
• 272104-64-0 methyl 3-bromomethyl-2-phenylquinoline-4-carboxylate 
• 219312-89-7 (9H-fluoren-9-yl)methylpiperazine-1-carboxylate 

Downstream Products

• 270574-13-5 3-(4-Fmoc-piperazin-1-ylmethyl)-2-phenyl-quinoline-4-carboxylic Acid ((S)-1-cyclohexyl-ethyl)-amide 
• 270574-12-4 4-[2-phenyl-4-(1-phenyl-propylcarbamoyl)-quinolin-3-ylmethyl]-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester 
• 748120-34-5 3-[4-(9H-fluoren-9-ylmethoxycarbonyl)-piperazin-1-ylmethyl]-2-phenyl-quinoline-4-carboxylic acid 

Relevant academic research and scientific papers

Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists

Certain compounds of formula (I) below or a pharmaceutically acceptable salt or hydrate thereof: (I) wherein: R1 is H or C1-6 alkyl; R2 is aryl or C3-7 cycloalkyl or heteroaryl; R3 is H or C1-3

Stepwise modulation of neurokinin-3 and neurokinin-2 receptor affinity and selectivity in quinoline tachykinin receptor antagonists

A stepwise chemical modification from human neurokinin-3 receptor (hNK-3R)-selective antagonists to potent and combined hNK-3R and hNK-2R antagonists using the same 2-phenylquinoline template is described. Docking studies with 3-D models of the hNK-3 and