270575-91-2Relevant articles and documents
Studies towards the identification of putative bioactive conformation of potent vasodilator arylidene N-acylhydrazone derivatives
Kuemmerle, Arthur E.,Raimundo, Juliana M.,Leal, Carla M.,da Silva, Givanildo S.,Balliano, Tatiane L.,Pereira, Mariano A.,de Simone, Carlos A.,Sudo, Roberto T.,Zapata-Sudo, Gisele,Fraga, Carlos A.M.,Barreiro, Eliezer J.
experimental part, p. 4004 - 4009 (2009/12/04)
In this report we disclose the synthesis, vasodilatory activity, and identification of bioactive conformation of new N-acylhydrazone and N-methyl-N-acylhydrazone derivatives, structurally designed by bioisosteric replacements of previously described cardioactive compounds LASSBio-294 and its N-methyl derivative LASSBio-785. Some of these novel derivatives presented improved vasorelaxant properties, being new cardiovascular drug candidates.
