27067-72-7

Upstream product

• 466-96-6 allopseudocodeine 
• 467-08-3 6β-chloro-4,5α-epoxy-3-methoxy-17-methyl-morphin-7-ene 

Downstream Products

• 57-27-2 (+/-)-morphine 
• 63783-54-0 O-acetylisocodeine 
• 120094-77-1 isocodeine benzyl dithiocarbonate 
• 466-95-5 8β-chloro-4,5α-epoxy-3-methoxy-17-methyl-morphin-6-ene 
• 52-28-8 codeine phosphate 
• 115-37-7 thebaine 

Relevant academic research and scientific papers

A total synthesis of (±)-codeine by 1,3-dipolar cycloaddition

Nitrone cycloaddition on a dearomatized bicyclic phenol enabled the facile construction of the correctly configured phenanthrene skeleton of codeine. Further steps yielded allopseudocodeine in a completely diastereoselective manner and finally (±)-codeine by allylic transposition through the hydrolysis of chlorocodides.

SYNTHESIS OF MORPHINE AND RELATED DERIVATIVES

The present invention relates to methods for the synthesis of galanthamine, morphine, intermediates, salts and derivatives thereof, wherein the starting compound is biphenyl.

Process for converting neopinone to codeinone

A process for converting neopinone alkaloid to codeinone alkaloid which involves treating neopinone with a hydrohalic acid in a suitable solvent under anhydrous conditions. It also relates to the compound 8-halodihydrocodeinone hydrohalide.