27074-57-3

Basic information

• Product Name: Morpholine, 4-(difluoroacetyl)- (8CI,9CI)
• Synonyms: Morpholine, 4-(difluoroacetyl)- (8CI,9CI)
• CAS NO: 27074-57-3
• Molecular Formula: C6H9F2NO2
• Molecular Weight: 165.1379664
• Product Categories: ACETYLHALIDE
• Mol File: 27074-57-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 80 °C(Press: 4 Torr)
• Appearance: /
• Density: 1.259±0.06 g/cm3(Predicted)
• PKA: -1.71±0.20(Predicted)
• CAS DataBase Reference: Morpholine, 4-(difluoroacetyl)- (8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Morpholine, 4-(difluoroacetyl)- (8CI,9CI)(27074-57-3)
• EPA Substance Registry System: Morpholine, 4-(difluoroacetyl)- (8CI,9CI)(27074-57-3)

Safety Data

• Hazardous Substances Data: 27074-57-3(Hazardous Substances Data)

Upstream product

• 39205-49-7 2,2-dichloro-1-morpholinoethan-1-one 
• 1338090-88-2 (S)-2,2-dioxo-1,2,3-oxathiazolidine-3,4-dicarboxylic acid 3-tert-butyl ester 4-ethyl ester 
• 149229-27-6 2-bromo-2,2-difluoro-1-morpholine-1-yl-ethanone 
• 29412-94-0 4-(1,1,2,2-tetrafluoro-ethyl)-morpholine 
• 110-91-8 morpholine 
• 381-72-6 difluoroacetyl chloride 

Downstream Products

• 114829-07-1 ω,ω-Difluoro-4-methoxyacetophenone 

Relevant articles and documents

Ring opening reactions of cyclic sulfamidates. Synthesis of β-fluoroaryl alanines and derivatives of 4,4-difluoroglutamic acid

Ring opening reactions of 1 with copper complex formed between Cu, TMEDA and BrCF2CO2Et lead to optically active 4,4-difluoroglutamic acid derivatives 11a-d in moderate yields. Reaction of cyclic sulfamidates 1 with fluoro substituted arylmagnesium chlorides proceed via copper catalyzed 1,4-addition of Grignard reagent to dehydroalanine 2, formed in situ. Fluorinated organoznic derivatives were unreactive towards 1 regardless of the reaction conditions; instead product of reaction of 1 with DMF was isolated.

Substituted Nitrogen Heterocycles and Synthesis and Uses Thereof

The invention relates to a nitrogen heterocycle compound of formula 1: Also disclosed are a method of synthesizing the compound and use of the compound for treating various diseases and conditions.