270918-02-0Relevant articles and documents
Synthesis and biological activities of NB-506 analogues modified at the glucose group
Ohkubo, Mitsuru,Nishimura, Teruyuki,Kawamoto, Hiroshi,Nakano, Masato,Honma, Teruki,Yoshinari, Tomoko,Arakawa, Hiroharu,Suda, Hiroyuki,Morishima, Hajime,Nishimura, Susumu
, p. 419 - 422 (2000)
A new indolocarbazole compound, NB-506 (1), modified at the glucose group yielded a β-D-glucopyranoside, J-107,088 (2), which showed potent anticancer activity. A β-D-ribofuranoside, J-109,534 (3), was found to be 6 times more potent than J-107,088 at inhibiting topoisomerase I. (C) 2000 Elsevier Science Ltd. All rights reserved.