174402-52-9

Upstream product

• 174402-51-8 2,5-dihydro-3,4-bis-(6-benzyloxy-1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione 

Downstream Products

• 174402-48-3 12,13-dihydro-2,10-dibenzyloxy-13-(β-D-2,3,4,6-tetra-O-benzylglucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-6-methyl-5,7(6H)-dione 
• 270918-08-6 C₆₁H₅₁N₃O₈ 
• 270918-14-4 C₆₂H₅₃N₃O₈ 
• 270918-11-1 C₅₄H₄₅N₃O₇ 
• 270918-03-1 C₆₁H₅₁N₃O₈ 
• 270918-10-0 C₆₉H₅₉N₃O₉ 
• 270918-09-7 C₆₉H₅₉N₃O₉ 
• 270918-04-2 C₆₉H₅₉N₃O₉ 
• 1390624-53-9 C₉₆H₈₇N₃O₁₄ 
• 270918-02-0 C₆₉H₅₉N₃O₉ 
• 73697-65-1 Arcyriaflavin C 
• 270918-05-3 C₆₂H₅₃N₃O₈ 
• 188884-46-0 C₆₁H₅₁N₃O₈ 

Relevant academic research and scientific papers

PROCESS FOR PRODUCING INDOLOPYRROLOCARBAZOLE DERIVATIVE

The present invention provides a process for industrially advantageously producing a compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, which is useful as an anticancer agent, and also provides a catalyst used for hydrogenation reaction in the process.

Processes for the preparation of indolopyrrolocarbazole derivatives

This invention relates to processes for the preparation of intermediates which are useful in the synthesis of compounds of the general formula or pharmaceutically salts thereof, wherein R1 and R2 each represent an OH group, R1/

Synthesis and biological activities of NB-506 analogues: Effects of the positions of two hydroxyl groups at the indole rings

In the course of a study of 6-N-amino-substituted analogues of NB-506 (1), a more potent anticancer drag, J-109,404 (2), in which the formyl group of NB-506 was replaced with a 1,3-dihydroxypropane group, was reported. A study of further modification in the positions of two hydroxyl groups at the indole rings of 2 resulted in the discovery of a 2,10-dihydroxy analogue, J- 107,088 (3), which is a promising anticancer agent with a broader therapeutic window than J-109,404.

Practical synthesis of indolopyrrolocarbazoles

A practical method for the synthesis of an indolo[2,3-a]pyrrolo[3,4- c]carbazole ring system is described. The method involves two key processes: a coupling reaction between indole and substituted methylmaleimide portions using lithium hexamethyldisilazide (LiHMDS) as a base, and the oxidative cyclization of bisindolylmaleimide with palladium (II) chloride. We applied this method to the synthesis of arcyriaflavin B (5), C (6) and D (7).