27097-66-1

Upstream product

• 110-91-8 morpholine 
• 547-64-8 methyl lactate 
• 97-64-3 ethyl 2-hydroxypropionate 

Downstream Products

• 827308-05-4 2-benzyloxy-1-(morpholin-4-yl)-1-propanone 
• 918819-06-4 (+/-)-2-(4-methoxybenzyloxy)-1-morpholinopropan-1-one 
• 5117-12-4 N-Acryloylmorpholine 

Relevant academic research and scientific papers

Preparation method for oxo-propenylmorpholine

The invention relates to a preparation method for oxo-propenylmorpholine, which includes the steps of: performing an aminolysis reaction with polylactic acid and morpholine as raw materials; and then performing an elimination reaction under the effect of a catalyst to produce the oxo-propenylmorpholine, wherein in the aminolysis reaction, reaction temperature is 50-180 DEG C, reaction time is 1-24 h and reaction pressure is 1-5 atm; the molecular weight of the polylactic acid is 500-100000; and the molar ratio of the polylactic acid to morpholine is 1:1-2. In the method, the polylactic acid and morpholine are used as raw materials, so that the method is beneficial to recovery of the polylactic acid and reduces material cost. The method is high in yield and the product is easy to purify. The method is less in reaction steps and simple in operation and is free of generation of an acidic gas, HCl, during the reactions, so that corrosion on reaction equipment is avoided.

Enantioselective microbial hydrolysis of dissymmetrical cyclic carbonates with disubstitution

Enantioselective microbial hydrolysis of C1 and C2 dissymmetrical cyclic carbonates with disubstitution (methyl and another groups) has been developed. Pseudomonas diminuta (FU0090), a bacterium, efficiently catalyzes the hydrolysis of five-membered cyclic carbonates. While the trans-substrates are hydrolyzed with low enantioselectivities and/or reactivities, the microbe hydrolyzes the cis-substrates with very high enantioselectivities to afford the corresponding almost optically pure anti-(2R,3S)-diols. On the other hand, six-membered trans-cyclic carbonates are enantioselectively hydrolyzed to afford the corresponding optically active syn-(2R,4R)-diols, although the hydrolysis of the cis-substrates gives racemic compounds. In all cases, the enzyme prefers the (R)-enantiomer for the carbon atom bearing a methyl group.

Enantioselective hydrogenation of α-ketoamides over Pt/A12O3 modified by cinchona alkaloids

Pyruvamide and its N-alkylated derivatives have been synthesised and hydrogenated enantioselectively to the corresponding alcohols over an alumina-supported Pt catalyst chirally modified by adsorbed cinchonidine. Depending on the substrate structure and r