27106-49-6 Usage
Description
1-[(4-Fluorophenyl)sulfonyl]piperazine, with the molecular formula C10H13FN2O2S, is an organic molecule characterized by a piperazine ring to which a sulfonyl group is attached at a 4-fluorophenyl group. 1-[(4-FLUOROPHENYL)SULFONYL]PIPERAZINE is recognized for its potential applications in the pharmaceutical and agrochemical industries, particularly due to its antipsychotic, antidepressant, and anxiolytic properties. It is also under investigation for its possible role in treating neurological disorders and cancer, making it a significant entity in medicinal chemistry research and drug discovery.
Uses
Used in Pharmaceutical Research and Development:
1-[(4-FLUOROPHENYL)SULFONYL]PIPERAZINE is used as a chemical intermediate for the synthesis of various pharmaceutical compounds due to its unique structure and properties that can be leveraged in drug design.
Used in Agrochemical Research and Development:
1-[(4-FLUOROPHENYL)SULFONYL]PIPERAZINE is used as a precursor in the development of agrochemicals, potentially contributing to the creation of new pesticides or herbicides.
Used in Antidepressant Applications:
1-[(4-FLUOROPHENYL)SULFONYL]PIPERAZINE is used as a potential antidepressant agent for its capacity to modulate neurotransmitter levels and influence mood regulation.
Used in Antipsychotic Applications:
1-[(4-FLUOROPHENYL)SULFONYL]PIPERAZINE is used as a potential antipsychotic agent, potentially aiding in the management of psychotic symptoms by interacting with specific receptors in the brain.
Used in Anxiolytic Applications:
1-[(4-FLUOROPHENYL)SULFONYL]PIPERAZINE is used as a potential anxiolytic agent, potentially helping to reduce anxiety by affecting the central nervous system.
Used in Neurological Disorder Treatment:
1-[(4-FLUOROPHENYL)SULFONYL]PIPERAZINE is used as a candidate for the treatment of neurological disorders, potentially offering therapeutic benefits through its interaction with neurological pathways.
Used in Cancer Treatment Research:
1-[(4-FLUOROPHENYL)SULFONYL]PIPERAZINE is used in cancer research as a potential anticancer agent, being studied for its ability to target and affect cancer cells.
Check Digit Verification of cas no
The CAS Registry Mumber 27106-49-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,1,0 and 6 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 27106-49:
(7*2)+(6*7)+(5*1)+(4*0)+(3*6)+(2*4)+(1*9)=96
96 % 10 = 6
So 27106-49-6 is a valid CAS Registry Number.
InChI:InChI=1/C10H13FN2O2S/c11-9-1-3-10(4-2-9)16(14,15)13-7-5-12-6-8-13/h1-4,12H,5-8H2
27106-49-6Relevant articles and documents
Further SAR on the (Phenylsulfonyl)piperazine Scaffold as Inhibitors of the Aedes aegypti Kir1 (AeKir) Channel and Larvicides
Aretz, Christopher D.,Kharade, Sujay V.,Chronister, Keagan,Rusconi Trigueros, Renata,Martinez Rodriguez, Erick J.,Piermarini, Peter M.,Denton, Jerod S.,Hopkins, Corey R.
, p. 319 - 327 (2021)
Zika virus (ZIKV), dengue fever (DENV) and chikungunya (CHIKV) are arboviruses that are spread to humans from the bite of an infected adult female Aedes aegypti mosquito. As there are no effective vaccines or therapeutics for these diseases, the primary strategy for controlling the spread of these viruses is to prevent the mosquito from biting humans through the use of insecticides. Unfortunately, the commonly used classes of insecticides have seen a significant increase in resistance, thus complicating control efforts. Inhibiting the renal inward rectifier potassium (Kir) channel of the mosquito vector Aedes aegypti has been shown to be a promising target for the development of novel mosquitocides. We have shown that Kir1 channels play key roles in mosquito diuresis, hemolymph potassium homeostasis, flight, and reproduction. Previous work from our laboratories identified a novel (phenylsulfonyl)piperazine scaffold as potent AeKir channel inhibitors with activity against both adult and larval mosquitoes. Herein, we report further SAR work around this scaffold and have identified additional compounds with improved in vitro potency and mosquito larvae toxicity.
Synthesis and antibacterial activity of novel myricetin derivatives containing sulfonylpiperazine
He, Jun,Tang, Xue-Mei,Liu, Ting-Ting,Peng, Feng,Zhou, Qing,Liu, Li-Wei,He, Ming,Xue, Wei
, p. 1021 - 1027 (2020/10/02)
Myricetin derivatives containing sulfonylpiperazine were synthesized and their structures were confirmed by NMR and HRMS. The antibacterial activity results indicated that some compounds showed good antibacterial activity against Xanthomonas oryzaepv. ory
Sulfonylpiperazines based on a flavone as antioxidant and cytotoxic agents
Patel, Rahul V.,Mistry, Bhupendra M.,Syed, Riyaz,Parekh, Nikhil M.,Shin, Han-Seung
, (2019/09/09)
Chrysin-based sulfonylpiperazines 7a-k were synthesized and investigated for their in vitro free radical scavenging potential as well as cytotoxic efficacies against selected cancer cell lines. Cytotoxicity of the new compounds toward noncancer cells was
