27113-22-0Relevant articles and documents
Stereoselective Biocatalyzed Reductions of Ginger Active Components Recovered from Industrial Wastes
Nasti, Rita,Bassanini, Ivan,Ferrandi, Erica Elisa,Linguardo, Federica,Bertuletti, Susanna,Vanoni, Marta,Riva, Sergio,Verotta, Luisella,Monti, Daniela
, (2022/03/08)
Ginger is among the most widespread and widely consumed traditional medicinal plants around the world. Its beneficial effects, which comprise e. g. anticancer and anti-inflammatory activities as well as gastrointestinal regulatory effects, are generally attributed to a family of non-volatile compounds characterized by an arylalkyl long-chained alcohol, diol, or ketone moiety. In this work, ginger active components have been successfully recovered from industrial waste biomass of fermented ginger. Moreover, their recovery has been combined with the first systematic study of the stereoselective reduction of gingerol-like compounds by isolated alcohol dehydrogenases (ADHs), obtaining the enantioenriched sec-alcohol derivatives via a sustainable biocatalytic path in up to >99 % conversions and >99 % enantiomeric/diastereomeric excesses.
Synthesis method of paradol
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, (2021/03/11)
The invention discloses a synthesis method of paradol. The synthesis method comprises the following synthesis steps: 1, carrying out alkylation reaction on 4-chloromethyl-2-methoxyphenyl acetate serving as a raw material and diethyl malonate under the action of alkali, and carrying out acylation reaction on the reaction product and capryloyl chloride under the action of alkali to generate 2-(4-acetoxy-3-methoxyphenyl)-2-octanoyl diethyl malonate; and 2, carrying out hydrolysis reaction on 2-(4-acetoxy-3-methoxyphenyl)-2-octanoyl diethyl malonate in acid and water to obtain the target product paradol. The synthesis method is simple and convenient to operate, does not need special reaction conditions, and is more suitable for industrial production.
GINGEROL DERIVATIVE HAVING INHIBITORY ACTIVITY AGAINST BIOFILM FORMATION AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS EFFECTIVE INGREDIENT FOR PREVENTING OR TREATING BIOFILM-CAUSED INFECTION SYMPTOM
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, (2020/09/22)
The present invention relates to a gingerol derivative having inhibitory activity against biofilm formation and a pharmaceutical composition for preventing or treating infections caused by biofilms including the gingerol derivative as an active ingredient. The gingerol derivative of the present invention exhibits significantly improved binding affinity for LasR and inhibitory activity against biofilm formation. Therefore, the gingerol derivative of the present invention can act on various membrane surfaces where biofilms tend to form and can effectively inhibit the formation of the corresponding biofilms. In addition, the use of the pharmaceutical composition according to the present invention can fundamentally prevent or treat a variety of infections caused by biofilms due to the presence of the gingerol derivative in the pharmaceutical composition.