878006-06-5

Basic information

• Product Name: 1-Decen-3-one, 1-(4-hydroxy-3-Methoxyphenyl)-, (1E)-
• Synonyms: 1-Decen-3-one, 1-(4-hydroxy-3-Methoxyphenyl)-, (1E)-;(E)-[6]-Dehydroparadol
• CAS NO: 878006-06-5
• Molecular Formula: C17H24O3
• Molecular Weight: 276.37066
• Mol File: 878006-06-5.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Decen-3-one, 1-(4-hydroxy-3-Methoxyphenyl)-, (1E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Decen-3-one, 1-(4-hydroxy-3-Methoxyphenyl)-, (1E)-(878006-06-5)
• EPA Substance Registry System: 1-Decen-3-one, 1-(4-hydroxy-3-Methoxyphenyl)-, (1E)-(878006-06-5)

Safety Data

• Hazardous Substances Data: 878006-06-5(Hazardous Substances Data)

Usage

Chemical classification

Organic ketone
Velleral is an organic compound with a ketone functional group.

Natural sources

Essential oil of Cyperus scariosus and rhizome oil of Alpinia allughas
Velleral can be found in these natural sources, indicating its presence in the environment.

Odor

Sweet, spicy, and woody
The compound has a characteristic and pleasant aroma, making it suitable for use in perfumes and fragrances.

Applications

Perfumes and fragrances
Due to its appealing scent, velleral is a popular ingredient in the perfumery and fragrance industry.

Therapeutic properties

Potential antioxidant and anti-inflammatory effects
Velleral has been studied for its possible health benefits, including its antioxidant and anti-inflammatory properties.

Industrial and medicinal applications

Valuable compound
The unique chemical structure and properties of velleral make it useful in various industrial and medicinal applications.

Chemical structure

1-Decen-3-one, 1-(4-hydroxy-3-methoxyphenyl)-, (1E)-
This is the specific chemical structure of the compound, which contributes to its properties and applications.

Upstream product

• 821-55-6 2-Nonanone 
• 121-33-5 vanillin 
• 27113-22-0 [6]-paradol 
• 881-68-5 vanillin acetate 

Relevant articles and documents

GINGEROL DERIVATIVE HAVING INHIBITORY ACTIVITY AGAINST BIOFILM FORMATION AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS EFFECTIVE INGREDIENT FOR PREVENTING OR TREATING BIOFILM-CAUSED INFECTION SYMPTOM

The present invention relates to a gingerol derivative having inhibitory activity against biofilm formation and a pharmaceutical composition for preventing or treating infections caused by biofilms including the gingerol derivative as an active ingredient. The gingerol derivative of the present invention exhibits significantly improved binding affinity for LasR and inhibitory activity against biofilm formation. Therefore, the gingerol derivative of the present invention can act on various membrane surfaces where biofilms tend to form and can effectively inhibit the formation of the corresponding biofilms. In addition, the use of the pharmaceutical composition according to the present invention can fundamentally prevent or treat a variety of infections caused by biofilms due to the presence of the gingerol derivative in the pharmaceutical composition.

Structure-Activity Relationships of 6- and 8-Gingerol Analogs as Anti-Biofilm Agents

Pseudomonas aeruginosa is a causative agent of chronic infections in immunocompromised patients. Disruption of quorum sensing circuits is an attractive strategy for treating diseases associated with P. aeruginosa infection. In this study, we designed and synthesized a series of gingerol analogs targeting LasR, a master regulator of quorum sensing networks in P. aeruginosa. Structure-activity relationship studies showed that a hydrogen-bonding interaction in the head section, stereochemistry and rotational rigidity in the middle section, and optimal alkyl chain length in the tail section are important factors for the enhancement of LasR-binding affinity and for the inhibition of biofilm formation. The most potent compound 41, an analog of (R)-8-gingerol with restricted rotation, showed stronger LasR-binding affinity and inhibition of biofilm formation than the known LasR antagonist (S)-6-gingerol. This new LasR antagonist can be used as an early lead compound for the development of anti-biofilm agents to treat P. aeruginosa infections.

Ginger metabolites and uses thereof

The present application generally relates to the use of metabolites of ginger and analogs thereof for the treatment and prevention of diseases, including but not limited to, cancer.