271260-82-3Relevant academic research and scientific papers
Synthesis of unnatural amino acids via suzuki cross-coupling of enantiopure vinyloxazolidine derivatives
Sabat, Mark,Johnson, Carl R.
, p. 1089 - 1091 (2000)
(R and S)-α-Amino alcohols and α-amino acids, including 4-methoxyhomophenylalanine, with a variety of unnatural side chains have been synthesized via palladium-catalyzed cross-coupling Suzuki reactions. The key building blocks 1 and 2, synthesized from the common achiral precursor 2-butene-1,4-diol, were made enantiopure utilizing a Pseudomonas cepacia lipase-catalyzed kinetic resolution. The optimal conditions for the Suzuki cross-coupling and the subsequent oxidations of the resultant α-amino alcohols are described.
An oligomer-based approach to skeletal diversity in small-molecule synthesis
Spiegel, David A.,Schroeder, Frank C.,Duvall, Jeremy R.,Schreiber, Stuart L.
, p. 14766 - 14767 (2008/02/09)
Access to small molecules of widely varying molecular shapes has been identified as an enabling step in the discovery of biologically active materials. In this communication we introduce an approach to the systematic development of architecturally distinc
