271261-12-2

Basic information

• Product Name: (R)-2-(benzyloxycarbonyl)amino-4-(4-chloropyridin-2-yl)-1-butanol
• Synonyms: (R)-2-(benzyloxycarbonyl)amino-4-(4-chloropyridin-2-yl)-1-butanol
• CAS NO: 271261-12-2
• Molecular Weight: 334.802
• Mol File: 271261-12-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-(benzyloxycarbonyl)amino-4-(4-chloropyridin-2-yl)-1-butanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(benzyloxycarbonyl)amino-4-(4-chloropyridin-2-yl)-1-butanol(271261-12-2)
• EPA Substance Registry System: (R)-2-(benzyloxycarbonyl)amino-4-(4-chloropyridin-2-yl)-1-butanol(271261-12-2)

Safety Data

• Hazardous Substances Data: 271261-12-2(Hazardous Substances Data)

Upstream product

• 91103-38-7 (R)-(1-hydroxymethallyl)carbamic acid benzyl ester 
• 186759-45-5 (+/-)-(1-hydroxymethallyl)carbamic acid benzyl ester 
• 31139-36-3 dibenzyl dicarbonate 
• 40473-01-6 2-Bromo-5-chloro-pyridine 
• 271260-90-3 benzyl (4R)-2,2-dimethyl-4-vinyl-1,3-oxazolidine-3-carboxylate 

Relevant articles and documents

Synthesis of unnatural amino acids via suzuki cross-coupling of enantiopure vinyloxazolidine derivatives

(R and S)-α-Amino alcohols and α-amino acids, including 4-methoxyhomophenylalanine, with a variety of unnatural side chains have been synthesized via palladium-catalyzed cross-coupling Suzuki reactions. The key building blocks 1 and 2, synthesized from the common achiral precursor 2-butene-1,4-diol, were made enantiopure utilizing a Pseudomonas cepacia lipase-catalyzed kinetic resolution. The optimal conditions for the Suzuki cross-coupling and the subsequent oxidations of the resultant α-amino alcohols are described.