27147-07-5

Upstream product

• 67-66-3 chloroform 
• 2703-27-7 4-chloro-4'-hydroxyazobenzene 
• 106-47-8 4-chloro-aniline 
• 90-02-8 salicylaldehyde 
• 89-95-2 2-methyl-benzyl alcohol 

Downstream Products

• 222017-29-0 5-(p-chlorophenyl)azosalicylidene-4-phenyl-2-aminothiazole 
• 881012-28-8 2-[1-[5-(4-Chloro-phenylazo)-2-hydroxy-phenyl]-meth-(E)-ylidene-hydrazinocarbonyl]-N-phenyl-acetamide 
• 881012-29-9 N-(2-Chloro-phenyl)-2-[1-[5-(4-chloro-phenylazo)-2-hydroxy-phenyl]-meth-(E)-ylidene-hydrazinocarbonyl]-acetamide 
• 881012-30-2 N-(3-Chloro-phenyl)-2-[1-[5-(4-chloro-phenylazo)-2-hydroxy-phenyl]-meth-(E)-ylidene-hydrazinocarbonyl]-acetamide 

Relevant academic research and scientific papers

Novel edaravone-based azo dyes: Efficient synthesis, characterization, antibacterial activity, DFT calculations and comprehensive investigation of the solvent effect on the absorption spectra

The present study deals with designing and synthesizing novel dyes using the drug combination of edaravone and azo compounds which can be used as an indicator for anions and cations. The desired product synthesis was accomplished via a two-step process involving diazotizing the aromatic amines followed by the resultant salts coupling with edaravone. The resulting dyes were obtained with high yields under mild conditions. The structures of the dyes were identified with UV-vis, FT-IR, 1H NMR and 13C NMR spectra and CHN analysis. To investigate the solvatochromism effect, the interaction of different solvents with the selected dyes was evaluated using several parameters including the dielectric constant, refractive index, hydrogen bond donating ability, hydrogen bond accepting ability and dipolarity/polarizability scale. To achieve deep understanding about the stability and geometrical characteristics of the azo-hydrazo tautomers of the synthesized dyes and their UV-visible spectra prediction, some DFT calculations were also carried out on the synthesized dyes. The antibacterial activities of some synthesized compounds were also evaluated using the disk diffusion method. The results revealed different activity of the selected synthesized dyes for antibacterial tests against selected Gram positive and Gram negative bacteria.

Extending the scope of amantadine drug by incorporation of phenolic azo Schiff bases as potent selective inhibitors of carbonic anhydrase II, drug-likeness and binding analysis

A series of Amantadine-based azo Schiff base dyes 6a–6e have been synthesized and characterized by 1H NMR and 13C NMR and evaluated for their in vitro carbonic anhydrase II inhibition activity and antioxidant activity. All of the syn

Microwave-assisted synthesis and photochromic properties of new azo-imidazoles

A convenient, one-pot three-component synthesis of new photochromic azo-imidazoles (1a-1h) from the corresponding azo dyes (2a-2h), benzil and ammonium acetate under microwave irradiation were described and their photochromic properties were investigated.

Facile and Mild Synthesis and Characterization of Some New Diazo Dyes on the Basis of Schiff Bases in the Presence of Nanocrystalline Magnesium Oxide as a Base Catalyst under Solvent-free Conditions

In this research, some new diazo dyes including Schiff base have been synthesized by the condensation reaction between ethylenediamine and derivatives of salicylaldehyde containing diazo functional groups in the presence of nanocrystalline magnesium oxide

Synthesis and identification of some new 2,3-disubstituted 1,3-oxazepine-4,7-dione derivatives containing azo group and 1,3,4-thiadiazole moiety

Azoaldehyde derivatives (1a-f) were prepared through coupling reactions between diazonium salts of six primary aromatic amines and alkaline solution of 2-hydroxy benzaldehyde. Compounds (1a-f) were then introduced in acid-catalyzed condensation reactions with 2-amino-5-mercapto-1,3,4-thiadiazole to obtain six new azoimines (2a-f). (2+5) Cycloaddition of (2a-f) with each maleic and phthalic anhydrides respectivily gave nine new oxazepines (3a-f) and (4b, 4d, 4e). The synthesized compounds might have some biological activity.

New 1,3-diazabicyclo-[3.1.0]hex-3-ene photochromic azo dyes: Synthesis, characterization and spectroscopic studies

Ten new 1,3-diazabicyclo-[3.1.0]hex-3-ene-based azo dyes (3a-3k) were synthesized via three-component reaction between [3-(x-phenyl)aziridin-2-yl] (phenyl)methanone (x = 4-NO2, 3-NO2), NH4OAc and azo-coupled o-vanillin or

New 1,2,4-triazole-based azo-azomethine dyes. Part II: Synthesis, characterization, electrochemical properties and computational studies

A new series of monoiminated 1,2,4-triazole-based azo-azomethine dyes have been synthesized via condensation reaction of 4-amino-3-methyl-5-mercapto-1,2,4- triazole with various substituted azo-coupled salicylaldehyde. The dyes have been characterized by using FT-IR, UV-Vis and 1H NMR spectroscopic methods as well as elemental analysis. The electrochemical behavior of the dyes has been investigated by cyclic voltammetry in DMSO at five different scan rates. Solvatochromic behavior of the dyes has been also investigated in four organic solvents with different polarities. Furthermore, the 1H chemical shielding of the dyes were studied by the gauge independent atomic orbital (GIAO) method at the level of density functional theory (DFT).

Tetrabutylammonium hydrogen sulfate mediated domino reaction: Synthesis of novel benzopyran-annulated pyrano[2,3-c]pyrazoles

A tetrabutylammonium hydrogen sulfate (TBA-HS) mediated procedure for one pot synthesis of novel benzopyran-annulated pyrano[2,3-c]pyrazoles via domino/Knoevenagel-hetero-Diels-Alder reaction has been demonstrated.

Synthesis and antifungal screening of some new 1,3-diketo amino analogues

Few new 1,3-diketo amino compounds containing -NH-N = C linkage have been synthesized by incorporating chloro group at different positions and are reported along with their spectral data and antifungal properties.