271577-22-1Relevant articles and documents
Synthesis, crystal structure, and activity of pyrazole-based inhibitors of p38 kinase
Graneto, Matthew J.,Kurumbail, Ravi G.,Vazquez, Michael L.,Shieh, Huey-Sheng,Pawlitz, Jennifer L.,Williams, Jennifer M.,Stallings, William C.,Geng, Lifeng,Naraian, Ashok S.,Koszyk, Francis J.,Stealey, Michael A.,Xu, Xiangdong D.,Weier, Richard M.,Hanson, Gunnar J.,Mourey, Robert J.,Compton, Robert P.,Mnich, Stephen J.,Anderson, Gary D.,Monahan, Joseph B.,Devraj, Rajesh
, p. 5712 - 5719 (2008/03/30)
A series of pyrazole inhibitors of p38 mitogen-activated protein (MAP) kinase were designed using a binding model based on the crystal structure of 1 (SC-102) bound to p38 enzyme. New chemistry using dithietanes was developed to assemble nitrogen-linked s
