271583-48-3Relevant articles and documents
A facile synthesis of substituted phenylglycines
Davies, Antony J.,Ashwood, Michael S.,Cottrell, Ian F.
, p. 1095 - 1102 (2007/10/03)
A convenient scaleable process for the preparation of substituted phenylglycines 2 by a modified Strecker reaction is described. Bisulfite- mediated addition of benzylamine and cyanide anion to substituted benzaldehydes 3 gave the aminonitriles 4 which were hydrolysed in two steps to the N-protected amino acid 1. Debenzylation using catalytic transfer hydrogenation gave the title compounds in good yield.
