129592-98-9

Basic information

• Product Name: AMINO-O-TOLYL-ACETIC ACID
• Synonyms: ALPHA-AMINO-(2-METHYLPHENYL)ACETIC ACID;AMINO(2-METHYLPHENYL)ACETIC ACID;AMINO-O-TOLYL-ACETIC ACID;2-AMINO-2-(2-METHYLPHENYL)ACETIC ACID;RARECHEM AK ML 0522;Benzeneacetic acid, alpha-amino-2-methyl- (9CI);2-AMino-2-(o-tolyl)acetic acid;2-(2-Methylphenyl)glycine
• CAS NO: 129592-98-9
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.19
• Product Categories: GLYCINESCAFFOLD;pharmacetical
• Mol File: 129592-98-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 234-238℃ (decomposition)
• Boiling Point: 307.6 °C at 760 mmHg
• Flash Point: 139.9 °C
• Appearance: /
• Density: 1.2 g/cm³
• Vapor Pressure: 0.00031mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: 2-8°C
• CAS DataBase Reference: AMINO-O-TOLYL-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: AMINO-O-TOLYL-ACETIC ACID(129592-98-9)
• EPA Substance Registry System: AMINO-O-TOLYL-ACETIC ACID(129592-98-9)

Safety Data

• Hazardous Substances Data: 129592-98-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 56, p. 420, 1991 DOI: 10.1021/jo00001a077

InChI:InChI=1/C9H11NO2/c1-6-4-2-3-5-7(6)8(10)9(11)12/h2-5,8H,10H2,1H3,(H,11,12)

Upstream product

• 529-20-4 2-methylphenyl aldehyde 
• 611-15-4 1-methyl-2-vinyl-benzene 
• 92876-67-0 1-(2-methylphenyl)ethane-1,2-diol 
• 40291-39-2 ethyl 2-(2-methylphenyl)acetate 
• 70484-46-7 diethyl (2-methylphenyl)propanedioate 
• 129592-87-6 methyl 2-bromo-2-(2-methylphenyl)acetate 
• 271583-48-3 2-benzylamino-2-o-tolyl-acetamide 
• 271583-70-1 N-benzyl amino-(2-methylphenyl)acetonitrile 
• 271583-29-0 benzylamino-o-tolyl-acetic acid 
• 129592-94-5 methyl N-(trifluoroacetyl)-2-amino-2-(2-methylphenyl)acetate 
• 203314-21-0 2-(o-methylphenyl)malonic acid 

Downstream Products

• 173779-03-8 N-(4-methoxyphenyl)-1-(o-tolyl)methanimine 
• 1236046-48-2 (2-(pyridin-2’-yl)phenyl)(o-tolyl)methanone 

Relevant articles and documents

Synthesis of Unprotected 2-Arylglycines by Transamination of Arylglyoxylic Acids with 2-(2-Chlorophenyl)glycine

The transamination of α-keto acids with 2-phenylglycine is an effective methodology for directly synthesizing unprotected α-amino acids. However, the synthesis of 2-arylglycines by transamination is problematic because the corresponding products, 2-arylglycines, transaminate the starting arylglyoxylic acids. Herein, we demonstrate the use of commercially available l-2-(2-chlorophenyl)glycine as the nitrogen source in the transamination of arylglyoxylic acids, producing the corresponding 2-arylglycines without interference from the undesired self-transamination process.

N-Alkylation of Trifluoroacetamide with 2-Bromo Carboxylic Esters under PTC conditions: A New Procedure for the Synthesis of α-Amino Acids

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