27159-40-6Relevant academic research and scientific papers
Nickel-Catalyzed Regio- And Stereospecific C-H Coupling of Benzamides with Aziridines
Hirano, Koji,Miura, Masahiro,Xu, Shibo
supporting information, p. 5471 - 5475 (2021/07/26)
A nickel-catalyzed C-H coupling of 8-aminoquinoline-derived benzamides with aryl- and alkyl-substituted aziridines has been disclosed. The current strategy provides direct access to benzolactams by the C-H alkylation-intramolecular amidation cascade event with the concomitant removal of the aminoquinoline auxiliary. The regioselectivity of ring opening of aziridines can be controlled by the substituents. The reaction with chiral aziridines proceeds with inversion of configuration, thus suggesting an SN2-type nucleophilic ring-opening pathway.
Coupling of 1-alkyl-2-(bromomethyl)aziridines with lithium dialkylcuprates towards 1,2-dialkylaziridines
D'Hooghe, Matthias,Rottiers, Mario,Jolie, Robrecht,De Kimpe, Norbert
, p. 931 - 934 (2007/10/03)
The reactivity of 1-alkyl-2-(bromomethyl)aziridines with respect to lithium dialkylcuprates (Gilman reagents) has been evaluated for the first time, pointing to the conclusion that these substrates can be applied successfully as synthetic equivalents for
Inversion of stereochemistry in the Co2(CO)8-catalyzed carbonylation of aziridines to β-lactams. The first synthesis of highly strained trans-bicyclic β-lactams
Piotti, Marcelo E.,Alper, Howard
, p. 111 - 116 (2007/10/03)
β-Lactams were synthesized by the carbonylative ring expansion of aziridines catalyzed by dicobalt octacarbonyl under CO pressure. The active catalyst, cobalt tetracarbonyl anion, induces nucleophilic ring opening of the heterocycle, resulting in inversio
A MILD CYCLIZATION OF 2-AMINOALCOHOLS TO AZIRIDINES USING DIPHOSPHORUS TETRAIODIDE
Suzuki, Hitomi,Tani, Hiroyuki
, p. 2129 - 2130 (2007/10/02)
The reaction of 2-aminoalcohols with diphosphorus tetraiodide in benzene at room temperature leads to the corresponding aziridines in good to moderate yields.
