27160-23-2

Usage

Uses

Used in Organic Synthesis:
In the chemical industry, (Formylamino)malonic acid dimethyl ester is utilized as a reagent for the preparation of a wide range of organic compounds. Its ability to undergo hydrolysis, esterification, and condensation reactions makes it a valuable building block for synthesizing more complex organic molecules.
Used in Pharmaceutical Applications:
The pharmaceutical industry has also shown interest in (Formylamino)malonic acid dimethyl ester due to its potential applications in drug development. Its unique structure and reactivity may contribute to the creation of new pharmaceutical compounds with various therapeutic properties.

InChI:InChI=1/C6H9NO5/c1-11-5(9)4(7-3-8)6(10)12-2/h3-4H,1-2H3,(H,7,8)

Upstream product

• 98832-61-2 methyl N-(dicarbomethoxymethyl)methanimidate 
• 42937-74-6 dimethyl 2-(hydroxyimino)malonate 
• 53704-09-9 dimethyl 2-aminomalonate 
• 98832-61-2 methyl N-(dicarbomethoxymethyl)methanimidate 
• 50-00-0 formaldehyd 
• 64-18-6 formic acid 

Downstream Products

• 108877-63-0 formylamino-(3-hydroxy-4-methyl-phenyl)-malonic acid dimethyl ester 
• 113649-74-4 (4,4'-bis-dimethylamino-benzhydryl)-formylamino-malonic acid dimethyl ester 
• 103206-69-5 formylamino-[4-(4-nitro-phenyl)-piperazinomethyl]-malonic acid dimethyl ester 
• 16150-75-7 rac.-N-Benzyl-N-<β,β-dimethoxycarbonyl-β-formamido-aethyl>-asparaginsaeure-diaethylester 
• 110330-37-5 3,3-Dibenzoyl-1,1-bis-carbomethoxy-1-formamino-propan 
• 1314080-81-3 (R)-dimethyl 5-amino-4-cyano-1-formyl-3-phenyl-1H-pyrrole-2,2(3H)-dicarboxylate 
• 53704-09-9 dimethyl 2-aminomalonate 
• 100373-42-0 benzyl-formylamino-malonic acid dimethyl ester 
• 102240-84-6 (1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylmethyl)-formylamino-malonic acid diethyl ester 

Relevant academic research and scientific papers

A GENERAL METHOD FOR THE SYNTHESIS OF 1-SUBSTITUTED (OR UNSUBSTITUTED)-4-CARBOMETHOXY-2-IMIDAZOLIN-5-ONES

A general method for the synthesis of the title compounds by employing the reagent methyl N-(dicarbomethoxymethyl)methanimidate is described.The preparation, properties and reactions of the reagent are also reported.

Reagents for Bioorganic Synthesis. 2. Methyl N-(Dicarboxymethyl)methanimidate

Preparation, properties, and reactions of the reagent methyl N-(dicarbomethoxymethyl)methanimidate (1) are reported.Dropwise addition of dimethyl aminomalonate to refluxing trimethyl orthoformate/TFA afforded 1.Treatment of 1 with ammonia and various primary amines gave the corresponding unsubstituted and 1-substituted 4-carbomethoxy-5-hydroxyimidazoles 7-12, either as the parent hydroxy compounds (a) or as the (alkyl)ammonium salts (b).The reaction of 1 with water and sodium hydrosulfide provided dimethyl N-formylaminomalonate (13) and dimethyl N-(thioformyl)aminomalonate (14), respectively.The reaction of 1 with excess sodium hydrosulfide resulted in the formation of methyl N-(thioformyl)aminoacetate (17).Conversions of methylammonium 4-carbomethoxy-1-methylimidazol-5-olate (8b) and benzylammonium 4-carbomethoxy-1-benzylimidazol-5-olate (9b) into 5-(benzylamino)-4-(benzylcarbamoyl)-1-methylimidazole (18) and 1-benzyl-5-(benzylamino)-4-(benzylcarbamoyl)imidazole (19), respectively, were each accomplished in a single-pot procedure, employing phenylphosphonic dichloride as the key reagent.