27163-66-2

Usage

Physical state

Colorless to pale yellow liquid

Odor

Sweet

Solubility

Insoluble in water, soluble in organic solvents

Uses

a. Intermediate in the synthesis of pharmaceuticals
b. Intermediate in the synthesis of agrochemicals
c. Building block for the production of other organic compounds
d. Research chemical

Hazard classification

Classified as a hazardous substance

Precautions

a. Care should be taken when handling to avoid exposure
b. Proper storage to prevent environmental contamination

Upstream product

• 27163-65-1 1-(3-Chlor-phenyl)-cyclohexen-⁽¹⁾ 
• 542-18-7 cyclohexyl chloride 
• 108-90-7 chlorobenzene 
• 13248-54-9 cyclohexyl chloroformate 
• 110-82-7 cyclohexane 
• 36229-42-2 (3-chlorophenyl)magnesium bromide 
• 108-94-1 cyclohexanone 
• 108-85-0 1-bromocyclohexane 
• 63503-60-6 3-chlorophenylboronic acid 

Relevant academic research and scientific papers

Ruthenium-catalyzed para-selective oxidative cross-coupling of arenes and cycloalkanes

A novel, direct para-selective oxidative cross-coupling of benzene derivatives with cycloalkanes catalyzed by ruthenium was developed. A wide range of arenes bearing electron-withdrawing substituents was functionalized directly with simple cycloalkanes with high para-selectivity; arenes with electron-donating groups were mainly para-functionalized. Benzoic acid can be used directly.

Suzuki Cross-Couplings of Unactivated Secondary Alkyl Bromides and Iodides

The capacity to employ unactivated alkyl electrophiles as coupling partners will markedly increase the already exceptional utility of metal-catalyzed cross-coupling processes. This communication describes the development of a method that achieves the first Suzuki reactions of unactivated secondary alkyl bromides and iodides. The ability to couple readily available, easy-to-handle boronic acids is an attractive feature of this catalyst system. Copyright