271788-76-2Relevant academic research and scientific papers
Lipase-catalyzed transesterification of 2-hydroxy-2- (pentafluorophenyl)acetonitrile leading to (1R,2R)-and (1S,2S)-bis (pentafluorophenyl)ethane-1,2-diol
Sakai, Takashi,Miki, Yasushi,Tsuboi, Masashi,Takeuchi, Hiroaki,Ema, Tadashi,Uneyama, Kenji,Utaka, Masanori
, p. 2740 - 2747 (2000)
Optically pure (IR,2R)- and (1S,2S)-1,2-bis(pentafluorophenyl)ethane- 1,2-diol (1) were synthesized from key intermediates (R)- and (S)-2-hydroxy- 2-(pentafluorophenyl)acetonitrile (2), both of which were prepared by the lipase LIP-catalyzed transesterification (E - 465). The absolute configuration of (S)-2 was determined by X-ray structural analysis after transformation into (S)-a-cyano-2,3,4,5,6-pentafluorobenzyl (S)-6-methoxy-a- methyl-2-naphthaleneacetate (S,S)-9. In addition, the crystal structure of (S,S)-9 has an interesting well-ordered packing pattern which shows face-to- face stacking interactions and end-to-end parallel contacts between the pentafluorophenyl and 6-methoxynaphthyl groups of the adjacent molecules.
Intermolecular oxygen atom?π interaction in the crystal packing of chiral amino alcohol bearing a pentafluorophenyl group
Korenaga, Toshinobu,Tanaka, Hikaru,Ema, Tadashi,Sakai, Takashi
, p. 201 - 205 (2007/10/03)
Presence of an unique atom-to-face alcoholic oxygen atom?π interaction between a pentafluorophenyl group and alcoholic oxygen (O?π) has been demonstrated by X-ray analysis of the novel chiral amino alcohol instead of the well-known interaction between usu
