27205-24-9

Basic information

• Product Name: 3-(Ethylthio)butanal
• Synonyms: 3-(ethylthio)butyraldehyde;3-(Ethylthio)butanal;3-(Ethylmercapto)-butanal;3-ethylsuleenyl butyraldehyde;3-(Ethylthio)butal
• CAS NO: 27205-24-9
• Molecular Formula: C₆H₁₂OS
• Molecular Weight: 132.22
• EINECS: 248-321-7
• Mol File: 27205-24-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 189.9°Cat760mmHg
• Flash Point: 68.8°C
• Appearance: /
• Density: 0.949g/cm³
• Vapor Pressure: 0.557mmHg at 25°C
• Refractive Index: 1.457
• CAS DataBase Reference: 3-(Ethylthio)butanal(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Ethylthio)butanal(27205-24-9)
• EPA Substance Registry System: 3-(Ethylthio)butanal(27205-24-9)

Safety Data

• Hazardous Substances Data: 27205-24-9(Hazardous Substances Data)

Usage

Hazard

Moderately toxic by ingestion and skin contact. Low toxicity by inhalation. An eye irritant.

InChI:InChI=1/C6H12OS/c1-3-8-6(2)4-5-7/h5-6H,3-4H2,1-2H3

Upstream product

• 121-44-8 triethylamine 
• 75-08-1 ethanethiol 
• 123-73-9 crotonaldehyde 
• 56-23-5 tetrachloromethane 
• 123-73-9 trans-Crotonaldehyde 

Downstream Products

• 81008-52-8 6-ethylthio-3-hepten-2-one 
• 76938-92-6 6-ethylthio-4-hydroxyheptan-2-one 
• 1067606-17-0 2-(2,6-diethyl-4-methylphenyl)-5-[2-(ethylsulfonyl)propyl]cyclohexane-1,3-dione 
• 1067600-27-4 2-(2,6-diethyl-4-methylphenyl)-5-[2-(ethylsulfinyl)propyl]-cyclohexane-1,3-dione 
• 1067594-01-7 2-(2,6-diethyl-4-methylphenyl)-5-[2-(ethylthio)propyl]cyclohexane-1,3-dione 
• 87476-15-1 5-[2-(ethylthio)-propyl]-1,3-cyclohexanedione 
• 1258408-38-6 (S,E)-5-ethylthio-1-phenylhex-1-en-3-one 
• 68195-07-3 4-(3-ethylsulfanyl-butylidene)-2-phenyl-4H-oxazol-5-one 

Relevant articles and documents

Cyclohexyl clethodim synthesis process

The invention relates to a cyclohexyl clethodim synthesis process, which comprises: (1) preparing 3-ethylthiobutyraldehyde by using ethanethiol and crotonaldehyde as raw materials; 2) carrying out a reaction on the 3-ethylthiobutyraldehyde and sodium acetoacetate by using secondary amine as a catalyst to prepare 6-ethylthio-3-heptene-2-one; 3) carrying out addition cyclization on the 6-ethylthio-3-heptene-2-one and diethyl malonate, and carrying out hydrolysis decarboxylation to obtain 5-(2-ethylthiopropyl)cyclohexane-1,3-dione; 4) carrying out O-acylation on the 5-(2-ethylthiopropyl)cyclohexane-1,3-dione through propionyl chloride, and carrying out rearrangement to obtain acylated 5-(2-ethylthiopropyl)-2-propionyl-3-hydroxy-2-cyclohexene-1-one; and 5) carrying out a reaction on the 5-(2-ethylthiopropyl)-2-propionyl-3-hydroxy-2-cyclohexene-1-one and 3-chloro-2-propenyl amine hydrochloride to prepare clethodim. According to the invention, the clethodim crude oil with a content of largerthan 97% is obtained by using ethanethiol and crotonaldehyde as the raw materials through the five-step reaction, wherein the total yield is larger than 62%, and the two-step yield of the intermediate 3-chloro-2-propenyl hydroxylamine is larger than 92%; and the method can be used for industrial production and has a good market prospect.

NOVEL HERBICIDES

Cyclohexanedione compounds, and derivatives thereof, which are substituted in 5-position, are suitable for use as herbicides.

Rhodium-catalyzed reductive aldol reactions using aldehydes as the stoichiometric reductants

Chelated acyl rhodium hydrides, generated from the addition of [Rh(dppe)]ClO4 to β-sulfide-substituted aldehydes, can function as the stoichiometric reductants in reductive aldol processes. Unsaturated nitriles, esters, and ketones can be used as enolate equivalents, and a variety of simple α- and β-substituted aldehydes can be employed. The use of a second, more electrophilic, aldehyde allows three-component reactions to be performed. Copyright