272127-69-2Relevant academic research and scientific papers
Synthesis and NMR characterization of diphenyl α-(benzyloxycarbonylamino)benzyl-phosphonates and diphenyl 1-(benzyloxycarbonylamino)-alkyl phosphonates
Consiglio, Giuseppe A.,Failla, Salvatore,Finocchiaro, Paolo,Siracusa, Valentina
, p. 159 - 166 (1998)
A variety of the title phosphonic derivatives were synthesized in high yields starting from commercially available aldehydes. Complete NMR characterization is reported for all compounds, which are useful intermediates for the synthesis of the phosphorus a
Aminophosphonic derivatives of chromone. synthesis of novel chromone-3-(α-amino) methanephosphonic acids
Boduszek, Bogdan,Lipinskp, Margin,Kowalska, Maria W.
, p. 179 - 189 (2007/10/03)
Reactions of 3-formylchromones with benzyl carbamate and triphenyl phosphite in acetic acid lead to the corresponding diphenyl chromone-3-[α(-N-benzyloxycarbonyl)amino]methanephosphonates 2 in high yields. Deprotection of the Z-substituted diphenyl esters 2 by means of acetic hydrogen bromide solution and the subsequent hydrolysis by means of 20% aq. HCl, lead to the final chromone-3-(a-amino)methanephosphonic acids 4. Attempts of synthesis of the corresponding chromone-2- aminophosphonic derivatives by this way, have failed. On the other hand, chromone-2-(α-amino)methanephosphonic acid (6) was successfully obtained by an addition of tris(trimethylsilyl) phosphite to the aldimine, which was formed from the 2-formylchromone.
