42059-81-4

Basic information

• Product Name: 3-FORMYL-6-METHYLCHROMONE
• Synonyms: 6-METHYL-4-OXO-4 H-1-BENZOPYRAN-3-CARBOXALDEHYDE;6-METHYL-4-OXO-4H-CHROMENE-3-CARBALDEHYDE;3-FORMYL-6-METHYLCHROMONE;IFLAB-BB F2121-0035;6-Methyl-4-oxo-(4H)-1-benzopyrane-3-carboxaldehyde;3-Formyl-6-methylchromone,97%;4H-1-benzopyran-3-carboxaldehyde, 6-methyl-4-oxo-;4-keto-6-methyl-chromene-3-carbaldehyde
• CAS NO: 42059-81-4
• Molecular Formula: C₁₁H₈O₃
• Molecular Weight: 188.18
• Product Categories: Chromones;Aldehydes;Benzopyrans;Building Blocks;C10-C12;Carbonyl Compounds;Chemical Synthesis;Heterocyclic Building Blocks;Organic Building Blocks
• Mol File: 42059-81-4.mol
• Article Data: 39

Chemical Properties

• Melting Point: 172-173 °C(lit.)
• Boiling Point: 335.1 °C at 760 mmHg
• Flash Point: 150.3 °C
• Appearance: yellow powder
• Density: 1.364 g/cm³
• Vapor Pressure: 0.000123mmHg at 25°C
• Refractive Index: 1.664
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 3-FORMYL-6-METHYLCHROMONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FORMYL-6-METHYLCHROMONE(42059-81-4)
• EPA Substance Registry System: 3-FORMYL-6-METHYLCHROMONE(42059-81-4)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 42059-81-4(Hazardous Substances Data)

Usage

Chemical Properties

yellow powder

Uses

3-Formyl-6-methylchromone may be used in the preparation of series of Schiff′s bases, via reaction with aromatic sulfonamides, such as sulfanilamide, homosulfanilamide, 4-aminoethyl-benzenesulfonamide, a pyrimidinyl-substituted sulfanilamide derivative, sulfaguanidine and 4-amino-6-trifluoromethyl-benzene-1,3-disulfonamide. It may be used in the preparation of Schiff base, which undergoes addition reaction with diethyl phosphite to afford bis[(1,2,4,3-triazaphospholyl)(chromonyl)aminomethylphosphonate] derivative and bis[(1,2,4,3-triazaphospholyl)(chromonyl)phosphorylamino-methylphosphonate] derivative.

General Description

3-Formyl-6-methylchromone is a 3-formyl-substituted chromone. The combustion calorimetric estimation of the enthalpy of combustion of 3-formyl-6-methylchromone has been reported. Its anti-proliferative action on the MDR human colon cancer and mouse lymphoma has been investigated.

InChI:InChI=1/C11H8O3/c1-7-2-3-10-9(4-7)11(13)8(5-12)6-14-10/h2-6H,1H3

Upstream product

• 1163120-27-1 3-(1-hydroxybut-3-en-1-yl)-6-methylchromone 
• 613-84-3 2-hydroxy-5-methylbenzaldehyde 
• 68-12-2 N,N-dimethyl-formamide 
• 145070-48-0 α-hydroxy-2'-methylacetophenone 
• 140-39-6 1-acetoxy-4-methylbenzene 
• 106-44-5 p-cresol 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 

Downstream Products

• 68827-55-4 4,5-Diphenyl-2-(6'-methyl-4'(H)-oxo-1-benzopyran-3'-yl)-imidazol 
• 71121-86-3 2,6-dimethyl-6H-benzo[b]chromeno[2,3-e][1,4]diazepin-13-one 
• 71121-87-4 2-methyl-6-phenyl-6H-benzo[b]chromeno[2,3-e][1,4]diazepin-13-one 
• 80031-00-1 (E)-1-(2-hydroxy-5-methylphenyl)-3-(piperidin-1-yl)prop-2-en-1-one 
• 99488-38-7 (2-Hydroxy-5-methyl-phenyl)-(1-methyl-1H-pyrrol-3-yl)-methanone 
• 99488-32-1 3-[4-(2-Hydroxy-5-methyl-benzoyl)-1H-pyrrol-2-yl]-6-methyl-chromen-4-one 
• 95664-46-3 (2-Amino-pyrimidin-5-yl)-(2-hydroxy-5-methyl-phenyl)-methanone 
• 84531-13-5 Ethyl 4-(2-hydroxy-5-methylbenzoyl)-1H-pyrrole-2-carboxylate 
• 101640-30-6 3-[1-(4-Chloro-phenylamino)-meth-(E)-ylidene]-2-ethoxy-6-methyl-chroman-4-one 
• 76369-09-0 3-{[(Z)-2-Amino-phenylimino]-methyl}-6-methyl-chromen-4-one 
• 114646-70-7 7-(2'-hydroxy-5'-methylbenzoyl)-3-phenyl-1,2,4-triazolo<3,4-b><1,3,4>thiadiazepine 
• 84531-08-8 4-(2-Hydroxy-5-methyl-benzoyl)-6-(6-methyl-4-oxo-4H-chromen-3-yl)-pyridine-2-carboxylic acid ethyl ester 
• 80472-48-6 3-acetyl-5-(2-hydroxy-5-methylbenzoyl)-2-methylpyridine 

Relevant articles and documents

Design and synthesis of chromone-nitrogen mustard derivatives and evaluation of anti-breast cancer activity

Chromone has emerged as one of the most important synthetic scaffolds for antitumor activity, which promotes the development of candidate drugs with better activity. In this study, a series of nitrogen mustard derivatives of chromone were designed and syn

Chromone 3-position nitric oxide donor derivative as well as preparation method and application thereof

The invention relates to the fields of natural medicines and medicinal chemistry, and relates to a preparation method of a series of chromone 3-position nitric oxide donor derivatives with antitumor activity and a new application of the chromone 3-position nitric oxide donor derivatives in preparation of antitumor medicines. The chromone 3-position nitric oxide donor derivative and the pharmaceutically acceptable salt thereof are shown as a general formula I in the specification. Wherein R and R1 are described in the claims and the specification.

Chromone 2-position nitric oxide donor derivative as well as preparation method and application thereof

The invention relates to the fields of natural medicines and medicinal chemistry, and relates to a preparation method of a series of chromone 2-position nitric oxide donor derivatives with antitumor activity and a new application of the chromone 2-position nitric oxide donor derivatives in preparation of antitumor medicines. The chromone 2-position nitric oxide donor derivative and the pharmaceutically acceptable salt thereof are shown as a general formula I in the specification. Wherein R and R1 are described in the claims and the specification.