27232-07-1Relevant academic research and scientific papers
Copper-catalyzed oxidative coupling between quinazoline 3-oxides and unactivated aldehydes: An efficient approach to functionalized quinazolines
Fan, Liwen,Wang, Tao,Tian, Ying,Xiong, Fei,Wu, Simei,Liang, Qingjin,Zhao, Junfeng
, p. 5375 - 5378 (2016)
A copper-catalyzed oxidative coupling between quinazoline 3-oxides and unactivated aldehydes was described. The reaction worked well for both aliphatic and aromatic aldehydes and produced not only the direct oxidative coupling ketones but also cyclic hydroxamic esters derived from quinazolines.
Method for efficiently preparing quinazolinone compound
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Paragraph 0011, (2016/10/10)
The invention discloses a method for efficiently preparing a quinazolinone compound. The method adopts 3-oxygen quinazoline and aldehyde as substrates, copper salt as the catalyst and 5.5 M tert-butyl hydroperoxide in decane as the oxidizing agent, and the quinazolinone compound is obtained through reaction at the temperature of 40 DEG C in the nitrogen atmosphere according to the reaction formula (1) (please see the formula in the description). One-step reaction of 3-oxygen quinazoline and aldehyde is achieved, the quinazolinone compound is more directly and simply synthesized, reaction is more direct and simpler, the substrates are small in limitation, reaction temperature is low, time is short, and potential application value is better achieved.
