2724-66-5

Usage

Uses

Used in Research Applications:
(2,4,6-Trichlorophenyl)hydrazine monohydrochloride is used as a research chemical for its distinct molecular structure, which allows for various chemical reactions and studies in the field of organic chemistry.
Used in Manufacturing Applications:
In the manufacturing industry, (2,4,6-Trichlorophenyl)hydrazine monohydrochloride is used as an intermediate or a building block in the synthesis of other compounds, contributing to the production of various chemical products. Its reactivity and molecular structure make it a valuable component in the creation of new materials and substances.

InChI:InChI=1/C6H5Cl3N2.ClH/c7-3-1-4(8)6(11-10)5(9)2-3;/h1-2,11H,10H2;1H

Upstream product

• 104891-98-7 3-Amino-3-(2,4,6-trichlor-phenylazo)propensaeuremethylester 
• 634-93-5 2,4,6-trichloroaniline 
• 99367-80-3 7-Amino-2,2-dimethyl-5-(2,4,6-trichloro-phenyl)-1-oxa-5,6-diaza-spiro[2.4]hept-6-en-4-one 

Downstream Products

• 138134-16-4 5-Isopropyl-1-(2,4,6-trichloro-phenyl)-1H-pyrazole-4-carbonitrile 
• 138134-05-1 1-<5-amino-1-(2,4,6,-trichlorophenyl)pyrazol-4-yl>-2-methylpropan-1-one 
• 138134-15-3 5-Propyl-1-(2,4,6-trichloro-phenyl)-1H-pyrazole-4-carbonitrile 
• 138134-04-0 1-<5-amino-1-(2,4,6-trichlorophenyl)pyrazol-4-yl>butan-1-one 
• 138134-18-6 3,5-diethyl-1-(2,4,6-trichlorophenyl)pyrazole-4-carbonitrile 
• 138134-07-3 1-[5-Amino-3-ethyl-1-(2,4,6-trichloro-phenyl)-1H-pyrazol-4-yl]-propan-1-one 
• 138134-17-5 5-Butyl-1-(2,4,6-trichloro-phenyl)-1H-pyrazole-4-carbonitrile 
• 138134-06-2 1-<5-amino-1-(2,4,6-trichlorophenyl)pyrazol-4-yl>pentan-1-one 
• 138134-14-2 5-ethyl-1-(2,4,6-trichlorophenyl)pyrazole-4-carbonitrile 
• 138134-03-9 1-<5-amino-1-(2,4,6-trichlorophenyl)pyrazol-4-yl>propan-1-one 
• 152713-62-7 5-Butyl-4-(2'-cyano-biphenyl-4-ylmethyl)-2-(2,4,6-trichloro-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester 
• 77635-53-1 N-[1-(2,4-Dimethoxy-phenyl)-eth-(E)-ylidene]-N'-(2,4,6-trichloro-phenyl)-hydrazine 
• 1252578-01-0 C₁₅H₁₀Cl₃N₅O 
• 1566598-91-1 ethyl 4-(2,4-dichlorophenyl)-5-phenyl-1-(2,4,6-trichlorophenyl)-1H-pyrazole-3-carboxylate 

Relevant academic research and scientific papers

Identification and Structure-Activity Relationships of Diarylhydrazides as Novel Potent and Selective Human Enterovirus Inhibitors

Enterovirus 71 (EV71) plays an important role in hand-foot-and-mouth disease. In this study, a series of diarylhydrazide analogues was synthesized, and the systematic exploration of SAR led to potent enterovirus inhibitors, of which compound 15 exhibits significant improvements in inhibition potency with an EC50 value of 0.02 μM against EV71. It is very interesting that this class of diarylhydrazides exhibits activities against a series of human enteroviruses at the picomolar level, including EV71 and Coxsackieviruses B1 (CVB1), CVB2, CVB3, CVB4, CVB5, and CVB6 (EC50 as low as 0.5 nM). Compared with the reference antienterovirus drug 1 (enviroxime) and known inhibitor 5 (WIN 51711), the four highly selective compounds 15, 27, 41 and 47 inhibited EV71 replication with EC50 values of 0.17-0.02 μM and SI values in a range of 978.4-12338. A preliminary mechanistic study indicated that VP1 might be the target site for this type of compound.

New Azoolefines and their Acidic Cleavage to Aryldiimines

3-Amino-1-aryl-3',3'-dimethyl-pyrazolin-4-spiro-2'-oxiran-5-ones (3a-c) undergo ring opening with methoxide forming methyl 3-amino-3-arylazo-propenoates (5a-c). 5a-c are cleaved under acidic conditions.The main products of the cleavage of 5c with methanolic hydrochloric acid are nitrogen, 2,4,6-trichloro-benzene (6), 2,4,6-trichloro-aniline (9) and 2,4,6-trichloro-phenylhydrazine (10).Intermediates of the cleavage of 5 are aryldiimines trapped with benzaldehyde as the corresponding benzhydrazides (12a,b).