27262-63-1

Basic information

• Product Name: Benzenepropanoic acid, a-diazo-b-hydroxy-b-methyl-, ethyl ester
• CAS NO: 27262-63-1
• Molecular Formula: C12H14N2O3
• Molecular Weight: 234.255
• Mol File: 27262-63-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, a-diazo-b-hydroxy-b-methyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, a-diazo-b-hydroxy-b-methyl-, ethyl ester(27262-63-1)
• EPA Substance Registry System: Benzenepropanoic acid, a-diazo-b-hydroxy-b-methyl-, ethyl ester(27262-63-1)

Safety Data

• Hazardous Substances Data: 27262-63-1(Hazardous Substances Data)

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 98-86-2 acetophenone 

Downstream Products

• 6963-62-8 ethyl 4-phenyl-1H-pyrazole-3-carboxylate 
• 5413-05-8 ethyl 2-phenylacetoacetate 
• 10488-87-6 ethyl 2-benzoylpropionate 
• 98-86-2 acetophenone 
• 126580-13-0 ethyl 2-diazo-3-phenyl-3-butenoate 
• 1620387-92-9 ethyl 2-chloro-3-oxo-2-phenylbutanoate 
• 1351162-65-6 6-acetyl-4-(ethoxycarbonyl)-3-phenylquinoline 1-oxide 
• 1351162-64-5 6-bromo-4-(ethoxycarbonyl)-3-phenylquinoline 1-oxide 
• 1351162-63-4 6-chloro-4-(ethoxycarbonyl)-3-phenylquinoline 1-oxide 
• 1351162-62-3 ethyl 6-methoxy-3-phenylquinoline-4-carboxylate 
• 1351162-61-2 4-(ethoxycarbonyl)-6-methoxy-3-phenylquinoline 1-oxide 
• 1351162-48-5 ethyl 3-phenylquinoline-4-carboxylate 
• 1351162-47-4 4-(ethoxycarbonyl)-3-phenylquinoline 1-oxide 

Relevant articles and documents

Intermolecular [5 + 1]-Cycloaddition between Vinyl Diazo Compounds and tert-Butyl Nitrite to 1,2,3-Triazine 1-Oxides and Their Further Transformation to Isoxazoles

1,2,3-Triazine 1-oxides are formed by nitrosyl addition from tert-butyl nitrite to the vinylogous position of vinyl diazo compounds. This transformation, which is a formal intermolecular [5 + 1] cycloaddition, occurs under mild conditions, with high funct

Ethyl Lithiodiazoacetate: Extremely Unstable Intermediate Handled Efficiently in Flow

Ethyl diazoacetate (EDA) is one of the most prominent diazo reagents. It is frequently used in metal–carbene-type reactions. However, EDA can also be used as a nucleophile under base catalysis. Whilst the addition of EDA to aldehydes can be performed using organic bases, the addition of EDA to other carbonyl electrophiles requires the use of organometallics such as lithium diisopropylamide (LDA). The generated ethyl lithiodiazoacetate is highly reactive and decomposes rapidly, even at low temperatures. Herein, we report a continuous flow protocol that overcomes the problems associated with the instantaneous decomposition of ethyl lithiodiazoacetate. The addition of ethyl lithiodiazoacetate to ketones provides direct access to tertiary diazoalcohols in good yields.

Pd-catalyzed coupling of β-hydroxy α-diazocarbonyl compounds with aryl iodides: A migratory insertion/β-hydroxy elimination sequence

The coupling of β-hydroxy α-diazocarbonyl compounds with aryl halides is described, which proceeds through a Pd-catalyzed migratory insertion/β-OH elimination sequence. This reaction provides a new route to the synthesis of tetrasubstituted olefins.