27285-09-2

Basic information

• Product Name: 1,2,3,4,5,6,7,8-OCTAHYDROBENZO[4,5]THIENO[2,3-D]PYRIMIDINE-2,4-DIONE
• Synonyms: 1,2,3,4,5,6,7,8-OCTAHYDROBENZO[4,5]THIENO[2,3-D]PYRIMIDINE-2,4-DIONE;5,6,7,8-Tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidine-2,4-diol
• CAS NO: 27285-09-2
• Molecular Formula: C₁₀H₁₀N₂O₂S
• Molecular Weight: 222.26
• Mol File: 27285-09-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 321 °C(Solv: acetic acid (64-19-7))
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.409g/cm³
• Refractive Index: 1.628
• PKA: 11.03±0.20(Predicted)
• CAS DataBase Reference: 1,2,3,4,5,6,7,8-OCTAHYDROBENZO[4,5]THIENO[2,3-D]PYRIMIDINE-2,4-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4,5,6,7,8-OCTAHYDROBENZO[4,5]THIENO[2,3-D]PYRIMIDINE-2,4-DIONE(27285-09-2)
• EPA Substance Registry System: 1,2,3,4,5,6,7,8-OCTAHYDROBENZO[4,5]THIENO[2,3-D]PYRIMIDINE-2,4-DIONE(27285-09-2)

Safety Data

• Hazardous Substances Data: 27285-09-2(Hazardous Substances Data)

Usage

General Description

1,2,3,4,5,6,7,8-OCTAHYDROBENZO[4,5]THIENO[2,3-D]PYRIMIDINE-2,4-DIONE is a chemical compound with a complex and specific structure. It belongs to the class of heterocyclic compounds and is also known as thienotriazolopyrimidine. It is an organic compound with potential biological activity and is commonly used in the field of medicinal chemistry. 1,2,3,4,5,6,7,8-OCTAHYDROBENZO[4,5]THIENO[2,3-D]PYRIMIDINE-2,4-DIONE has a unique molecular structure that makes it suitable for various pharmacological applications. Its properties and structure allow it to interact with specific biological targets, making it a valuable compound in drug discovery and development.

InChI:InChI=1/C10H10N2O2S/c13-8-7-5-3-1-2-4-6(5)15-9(7)12-10(14)11-8/h1-4H2,(H2,11,12,13,14)

Upstream product

• 57-13-6 urea 
• 4815-28-5 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide 
• 4506-71-2 ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 
• 108-94-1 cyclohexanone 
• 108354-78-5 methyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 
• 1312367-11-5 methyl 2-ureido-4,5,6,7-tetrahydrobenzo[b]thiophen-3-carboxylate 
• 100068-52-8 2-Aminocarbonylamino-3-ethoxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophene 
• 40277-35-8 2,4-dichloro-5,6,7,8-tetrahydrobenzothieno<2,3-d>pyrimidine 
• 75-44-5 phosgene 
• 27285-10-5 2-ethoxycarbonylamino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-carboxamide 
• 27285-13-8 2-(3-phenylurea)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide 
• 53162-03-1 Potassium; 4-oxo-3,4,5,6,7,8-hexahydro-benzo[4,5]thieno[2,3-d]pyrimidine-2-thiolate 

Downstream Products

• 40277-35-8 2,4-dichloro-5,6,7,8-tetrahydrobenzothieno<2,3-d>pyrimidine 

Relevant articles and documents

Heterocyclische β-Enaminoester; 35. Heteroanellierte Uracile mittels Chlorosulfonyl-isocyanat und sulfonyl-analoge Uracile mittels Sulfamidsaeure-chloriden

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FLT3 INHIBITORS AND USES THEREOF

The present invention provides methods of using compounds of formula I: or compositions thereof for the inhibition of FLT3, and the treatment of FLT3-mediated disorders.

Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1 H,3 H)-dione: Synthesis, molecular modeling, and pharmacological and biostructural characterization

The physiological function of kainate receptors (GluK1-GluK5) in the central nervous system is not fully understood yet. With the aim of developing potent and selective GluK1 ligands, we have synthesized a series of new thiophene-based GluK1 agonists (6a-c) and antagonists (7a-d). Pharmacological evaluation revealed that they are selective for the GluK1 subunit, with 7b being the most subtype-selective ligand reported to date (GluK1 vs GluK3). The antagonist 7a was cocrystallized with the GluK1 ligand binding domain, and an X-ray crystallographic analysis revealed the largest flexibility in GluK1 ligand binding domain opening upon binding of a ligand seen to date. The results provide new insights into the molecular mechanism of GluK1 receptor ligand binding and pave the way to the development of new tool compounds for studying kainate receptor function.